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    ACP7 acid phosphatase 7, tartrate resistant (putative) [ Homo sapiens (human) ]

    Gene ID: 390928, updated on 12-Aug-2022

    Summary

    Official Symbol
    ACP7provided by HGNC
    Official Full Name
    acid phosphatase 7, tartrate resistant (putative)provided by HGNC
    Primary source
    HGNC:HGNC:33781
    See related
    Ensembl:ENSG00000183760 MIM:610490; AllianceGenome:HGNC:33781
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAPL; PAPL1
    Summary
    Purple acid phosphatases (PAPs), including PAPL, are a family of binuclear metallohydrolases that have been identified in plants, animals, and fungi (Flanagan et al., 2006 [PubMed 16793224]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in skin (RPKM 2.2), brain (RPKM 0.3) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See ACP7 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39083788..39111493)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41888321..41915473)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39575008..39602133)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene F-box protein 27 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124904714 Neighboring gene p21 (RAC1) activated kinase 4 Neighboring gene uncharacterized LOC124904716

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ16165

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acid phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    acid phosphatase type 7
    Names
    iron/zinc purple acid phosphatase-like protein
    purple acid phosphatase long form 1
    NP_001004318.2
    NP_001350616.1
    XP_011525268.1
    XP_011525269.1
    XP_011525271.1
    XP_016882296.1
    XP_047294780.1
    XP_047294781.1
    XP_047294782.1
    XP_047294783.1
    XP_047294784.1
    XP_047294785.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004318.3NP_001004318.2  acid phosphatase type 7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001004318.2

      Status: VALIDATED

      Source sequence(s)
      AC011443, AK131245, BC142613
      Consensus CDS
      CCDS33018.1
      UniProtKB/Swiss-Prot
      B2RN68, Q6ZNF0
      Related
      ENSP00000327557.4, ENST00000331256.10
      Conserved Domains (2) summary
      cd00839
      Location:131429
      MPP_PAPs; purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain
      pfam16656
      Location:34124
      Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain
    2. NM_001363687.2NP_001350616.1  acid phosphatase type 7 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC011443
      Consensus CDS
      CCDS86764.1
      UniProtKB/TrEMBL
      M0R045
      Related
      ENSP00000470989.1, ENST00000594229.1
      Conserved Domains (2) summary
      pfam16656
      Location:34124
      Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain
      cl13995
      Location:131168
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      39083788..39111493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026807.3XP_016882296.1  acid phosphatase type 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RN68, Q6ZNF0
      Conserved Domains (2) summary
      cd00839
      Location:131429
      MPP_PAPs; purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain
      pfam16656
      Location:34124
      Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain
    2. XM_047438824.1XP_047294780.1  acid phosphatase type 7 isoform X2

    3. XM_011526966.4XP_011525268.1  acid phosphatase type 7 isoform X1

      See identical proteins and their annotated locations for XP_011525268.1

      UniProtKB/Swiss-Prot
      B2RN68, Q6ZNF0
      Conserved Domains (2) summary
      cd00839
      Location:131429
      MPP_PAPs; purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain
      pfam16656
      Location:34124
      Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain
    4. XM_047438825.1XP_047294781.1  acid phosphatase type 7 isoform X2

    5. XM_011526967.4XP_011525269.1  acid phosphatase type 7 isoform X2

      Conserved Domains (3) summary
      cd00839
      Location:131371
      MPP_PAPs; purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain
      pfam00149
      Location:135337
      Metallophos; Calcineurin-like phosphoesterase
      pfam16656
      Location:32124
      Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain
    6. XM_011526969.3XP_011525271.1  acid phosphatase type 7 isoform X4

      Conserved Domains (2) summary
      cd00839
      Location:131269
      MPP_PAPs; purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain
      pfam16656
      Location:32124
      Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain
    7. XM_047438827.1XP_047294783.1  acid phosphatase type 7 isoform X5

    8. XM_047438826.1XP_047294782.1  acid phosphatase type 7 isoform X3

    9. XM_047438828.1XP_047294784.1  acid phosphatase type 7 isoform X5

    10. XM_047438829.1XP_047294785.1  acid phosphatase type 7 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      41888321..41915473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)