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    PABPN1L poly(A) binding protein nuclear 1 like, cytoplasmic [ Homo sapiens (human) ]

    Gene ID: 390748, updated on 17-Jun-2019

    Summary

    Official Symbol
    PABPN1Lprovided by HGNC
    Official Full Name
    poly(A) binding protein nuclear 1 like, cytoplasmicprovided by HGNC
    Primary source
    HGNC:HGNC:37237
    See related
    Ensembl:ENSG00000205022
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ePABP2; PABPNL1
    Expression
    Ubiquitous expression in adrenal (RPKM 3.9), testis (RPKM 3.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See PABPN1L in Genome Data Viewer
    Location:
    16q24.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (88862623..88870152, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (88929746..88933068, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene proline-rich proteoglycan 2-like Neighboring gene galactosamine (N-acetyl)-6-sulfatase Neighboring gene uncharacterized LOC107983950 Neighboring gene trafficking protein particle complex 2 like Neighboring gene uncharacterized LOC101927793 Neighboring gene CBFA2/RUNX1 partner transcriptional co-repressor 3 Neighboring gene uncharacterized LOC102724632

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    embryonic polyadenylate-binding protein 2
    Names
    ePABP-2
    embryonic poly(A)-binding protein 2
    embryonic poly(A)-binding protein type II
    poly(A)-binding protein nuclear-like 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080487.2NP_001073956.2  embryonic polyadenylate-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001073956.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC130002, EU190484
      Consensus CDS
      CCDS45547.2
      UniProtKB/Swiss-Prot
      A6NDY0
      UniProtKB/TrEMBL
      B6RF28
      Related
      ENSP00000408598.2, ENST00000419291.6
      Conserved Domains (2) summary
      COG0724
      Location:138231
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12551
      Location:148224
      RRM_II_PABPN1L; RNA recognition motif in vertebrate type II embryonic polyadenylate-binding protein 2 (ePABP-2)
    2. NM_001294328.2NP_001281257.1  embryonic polyadenylate-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001281257.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC092384, BC130001
      Consensus CDS
      CCDS73925.1
      UniProtKB/Swiss-Prot
      A6NDY0
      Related
      ENSP00000405259.2, ENST00000411789.6
      Conserved Domains (2) summary
      COG0724
      Location:138191
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:148189
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      88862623..88870152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023230.1XP_016878719.1  embryonic polyadenylate-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A6NDY0
      Conserved Domains (2) summary
      COG0724
      Location:138231
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12551
      Location:148224
      RRM_II_PABPN1L; RNA recognition motif in vertebrate type II embryonic polyadenylate-binding protein 2 (ePABP-2)
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