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    OR4N2 olfactory receptor family 4 subfamily N member 2 [ Homo sapiens (human) ]

    Gene ID: 390429, updated on 11-Apr-2024

    Summary

    Official Symbol
    OR4N2provided by HGNC
    Official Full Name
    olfactory receptor family 4 subfamily N member 2provided by HGNC
    Primary source
    HGNC:HGNC:14742
    See related
    Ensembl:ENSG00000176294 AllianceGenome:HGNC:14742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR14-8; OR14-13
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a seven-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Mar 2014]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See OR4N2 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (19803770..19830253)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (14003230..14029714)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (20271929..20298412)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 4 subfamily M member 1 Neighboring gene olfactory receptor family 4 subfamily N member 1 pseudogene Neighboring gene olfactory receptor family 4 subfamily K member 6 pseudogene Neighboring gene olfactory receptor family 4 subfamily K member 3 (gene/pseudogene)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    olfactory receptor 4N2
    Names
    olfactory receptor OR14-13
    olfactory receptor OR14-8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034035.1 RefSeqGene

      Range
      5001..31484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001004723.3NP_001004723.1  olfactory receptor 4N2

      See identical proteins and their annotated locations for NP_001004723.1

      Status: VALIDATED

      Source sequence(s)
      AL391156
      Consensus CDS
      CCDS32022.1
      UniProtKB/Swiss-Prot
      Q6IEY9, Q6IFA2, Q8NGD1
      UniProtKB/TrEMBL
      A0A126GVT2, A0A126GWI9
      Related
      ENSP00000452022.2, ENST00000557677.3
      Conserved Domains (2) summary
      pfam00001
      Location:41287
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:35302
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      19803770..19830253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791796.1 Reference GRCh38.p14 PATCHES

      Range
      6452..32935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      14003230..14029714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)