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    RBM12B RNA binding motif protein 12B [ Homo sapiens (human) ]

    Gene ID: 389677, updated on 17-Sep-2024

    Summary

    Official Symbol
    RBM12Bprovided by HGNC
    Official Full Name
    RNA binding motif protein 12Bprovided by HGNC
    Primary source
    HGNC:HGNC:32310
    See related
    Ensembl:ENSG00000183808 AllianceGenome:HGNC:32310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MGC:33837
    Summary
    Enables RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 5.9), ovary (RPKM 4.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RBM12B in Genome Data Viewer
    Location:
    8q22.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (93728155..93741009, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (94853161..94866033, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (94740383..94753237, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene CIBAR1 divergent transcript Neighboring gene uncharacterized LOC105375641 Neighboring gene zinc finger protein 317 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:94712406-94713030 Neighboring gene CBY1 interacting BAR domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27619 Neighboring gene RBM12B antisense RNA 1 Neighboring gene RBM12B divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:94791793-94792322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:94792323-94792851 Neighboring gene transmembrane protein 67

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377960.1NP_001364889.1  RNA-binding protein 12B

      Status: VALIDATED

      Source sequence(s)
      AC010834
      Consensus CDS
      CCDS43755.1
      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Related
      ENSP00000429807.2, ENST00000520560.6
      Conserved Domains (7) summary
      PTZ00121
      Location:449680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:280
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:9251001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins
    2. NM_001377961.1NP_001364890.1  RNA-binding protein 12B

      Status: VALIDATED

      Source sequence(s)
      AC010834
      Consensus CDS
      CCDS43755.1
      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Conserved Domains (7) summary
      PTZ00121
      Location:449680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:280
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:9251001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins
    3. NM_001377962.1NP_001364891.1  RNA-binding protein 12B

      Status: VALIDATED

      Source sequence(s)
      AC010834
      Consensus CDS
      CCDS43755.1
      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Conserved Domains (7) summary
      PTZ00121
      Location:449680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:280
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:9251001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins
    4. NM_001377963.1NP_001364892.1  RNA-binding protein 12B

      Status: VALIDATED

      Source sequence(s)
      AC010834
      Consensus CDS
      CCDS43755.1
      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Related
      ENSP00000430474.2, ENST00000519109.6
      Conserved Domains (7) summary
      PTZ00121
      Location:449680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:280
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:9251001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins
    5. NM_001377964.1NP_001364893.1  RNA-binding protein 12B

      Status: VALIDATED

      Source sequence(s)
      AC010834
      Consensus CDS
      CCDS43755.1
      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Conserved Domains (7) summary
      PTZ00121
      Location:449680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:280
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:9251001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins
    6. NM_203390.4NP_976324.2  RNA-binding protein 12B

      See identical proteins and their annotated locations for NP_976324.2

      Status: VALIDATED

      Source sequence(s)
      AC010834, BC039260
      Consensus CDS
      CCDS43755.1
      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Related
      ENSP00000382239.2, ENST00000399300.7
      Conserved Domains (7) summary
      PTZ00121
      Location:449680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:280
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:9251001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      93728155..93741009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517029.3XP_011515331.1  RNA-binding protein 12B isoform X1

      See identical proteins and their annotated locations for XP_011515331.1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Related
      ENSP00000428269.2, ENST00000518597.2
      Conserved Domains (7) summary
      PTZ00121
      Location:449680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:280
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:9251001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins
    2. XM_047421772.1XP_047277728.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
    3. XM_017013408.3XP_016868897.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Related
      ENSP00000427729.2, ENST00000517700.6
      Conserved Domains (7) summary
      PTZ00121
      Location:449680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:280
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:9251001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins
    4. XM_047421773.1XP_047277729.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
    5. XM_047421771.1XP_047277727.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
    6. XM_047421776.1XP_047277732.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
    7. XM_047421774.1XP_047277730.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
    8. XM_047421770.1XP_047277726.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
    9. XM_047421775.1XP_047277731.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      94853161..94866033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360468.1XP_054216443.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
    2. XM_054360469.1XP_054216444.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
    3. XM_054360464.1XP_054216439.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
    4. XM_054360463.1XP_054216438.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
    5. XM_054360467.1XP_054216442.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
    6. XM_054360465.1XP_054216440.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
    7. XM_054360462.1XP_054216437.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
    8. XM_054360466.1XP_054216441.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1