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    ENO4 enolase 4 [ Homo sapiens (human) ]

    Gene ID: 387712, updated on 3-Apr-2024

    Summary

    Official Symbol
    ENO4provided by HGNC
    Official Full Name
    enolase 4provided by HGNC
    Primary source
    HGNC:HGNC:31670
    See related
    Ensembl:ENSG00000188316 MIM:131375; AllianceGenome:HGNC:31670
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ENOS; C10orf134
    Summary
    Predicted to enable phosphopyruvate hydratase activity. Predicted to be involved in glycolytic process and regulation of vacuole fusion, non-autophagic. Predicted to act upstream of or within cilium organization and flagellated sperm motility. Predicted to be located in sperm principal piece. Predicted to be part of phosphopyruvate hydratase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See ENO4 in Genome Data Viewer
    Location:
    10q25.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (116849499..116912375)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (117743799..117806708)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118609010..118642112)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene heat shock protein family A (Hsp70) member 12A Neighboring gene uncharacterized LOC105378498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118534387-118534886 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:118538206-118539405 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:118544309-118544475 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:118595447-118596082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4095 Neighboring gene microRNA 9851 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:118665638-118666837 Neighboring gene shootin 1 Neighboring gene Sharpr-MPRA regulatory region 1976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2857 Neighboring gene VISTA enhancer hs841 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118885664-118886164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118890627-118891154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118891155-118891681 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118899364-118899950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118899951-118900536 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:118918871-118919627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118925104-118925658 Neighboring gene MIR3663 host gene Neighboring gene ventral anterior homeobox 1 Neighboring gene microRNA 3663

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • AC023283.3

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables phosphopyruvate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    part_of phosphopyruvate hydratase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    enolase 4
    Names
    2-phospho-D-glycerate hydro-lyase
    enolase family member 4
    enolase-like protein ENO4
    NP_001229628.1
    XP_005269872.1
    XP_006717898.1
    XP_011538099.1
    XP_047281184.1
    XP_054221872.1
    XP_054221873.1
    XP_054221874.1
    XP_054221875.1
    XP_054221876.1
    XP_054221877.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242699.2NP_001229628.1  enolase 4

      Status: VALIDATED

      Source sequence(s)
      AC023283
      Consensus CDS
      CCDS73206.1
      UniProtKB/Swiss-Prot
      A0A087WZY6, A6NI74, A6NNW6, B8ZZN9, J3KNX1
      UniProtKB/TrEMBL
      A0A5H1ZRS3
      Related
      ENSP00000345555.6, ENST00000341276.11
      Conserved Domains (2) summary
      COG0148
      Location:66568
      Eno; Enolase [Carbohydrate transport and metabolism]
      cd22974
      Location:1478
      DD_ENO4; dimerization/docking (D/D) domain found in enolase 4 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      116849499..116912375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717835.4XP_006717898.1  enolase 4 isoform X1

      UniProtKB/TrEMBL
      A0A5H1ZRS3
      Conserved Domains (2) summary
      TIGR01060
      Location:68568
      eno; phosphopyruvate hydratase
      cl21457
      Location:70567
      TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
    2. XM_011539797.4XP_011538099.1  enolase 4 isoform X2

      UniProtKB/TrEMBL
      A0A5H1ZRS3
      Conserved Domains (2) summary
      TIGR01060
      Location:68526
      eno; phosphopyruvate hydratase
      cl21457
      Location:70525
      TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
    3. XM_047425228.1XP_047281184.1  enolase 4 isoform X3

    4. XM_005269815.4XP_005269872.1  enolase 4 isoform X4

      Conserved Domains (1) summary
      cl21457
      Location:70404
      TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      117743799..117806708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365897.1XP_054221872.1  enolase 4 isoform X1

    2. XM_054365898.1XP_054221873.1  enolase 4 isoform X2

    3. XM_054365899.1XP_054221874.1  enolase 4 isoform X3

    4. XM_054365900.1XP_054221875.1  enolase 4 isoform X5

    5. XM_054365901.1XP_054221876.1  enolase 4 isoform X6

    6. XM_054365902.1XP_054221877.1  enolase 4 isoform X4