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    Thoc6 THO complex 6 [ Mus musculus (house mouse) ]

    Gene ID: 386612, updated on 5-Aug-2018

    Summary

    Official Symbol
    Thoc6provided by MGI
    Official Full Name
    THO complex 6provided by MGI
    Primary source
    MGI:MGI:2677480
    See related
    Ensembl:ENSMUSG00000041319 Vega:OTTMUSG00000023716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wdr58; F830014G06Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 19.7), CNS E11.5 (RPKM 13.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Thoc6 in Genome Data Viewer
    Location:
    17; 17 A3.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (23668618..23673903, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (23805586..23810737, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene calcium binding protein 39-like pseudogene Neighboring gene matrix metallopeptidase 25 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene BICD family like cargo adaptor 2 Neighboring gene host cell factor C1 regulator 1 (XPO1-dependent) Neighboring gene tumor necrosis factor receptor superfamily, member 12a Neighboring gene claudin 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC107304, MGC109691

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    viral mRNA export from host cell nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    THO complex ISO
    Inferred from Sequence Orthology
    more info
     
    THO complex part of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nuclear chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription export complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    THO complex subunit 6 homolog
    Names
    WD repeat domain 58
    WD repeat-containing protein 58

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008425.2NP_001008425.1  THO complex subunit 6 homolog

      See identical proteins and their annotated locations for NP_001008425.1

      Status: VALIDATED

      Source sequence(s)
      AC154766, AI850888, BC085131, CX224561
      Consensus CDS
      CCDS28454.1
      UniProtKB/Swiss-Prot
      Q5U4D9
      Related
      ENSMUSP00000038137.4, OTTMUSP00000028009, ENSMUST00000047436.10
      Conserved Domains (2) summary
      sd00039
      Location:2874
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:31196
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001357380.1NP_001344309.1  THO complex subunit 6 homolog

      Status: VALIDATED

      Source sequence(s)
      AC154766, AI850888, BC085131, CO428739
      Conserved Domains (2) summary
      sd00039
      Location:2874
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:31196
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      23668618..23673903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524544.2XP_006524607.1  THO complex subunit 6 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5U4D9
      Related
      ENSMUSP00000093239.4, OTTMUSP00000028008, ENSMUST00000095579.10, OTTMUST00000057915
      Conserved Domains (2) summary
      sd00039
      Location:2874
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:31196
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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