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    S6k Ribosomal protein S6 kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38654, updated on 18-Apr-2019

    Summary

    Official Symbol
    S6kprovided by FlyBase
    Official Full Name
    Ribosomal protein S6 kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283472
    Locus tag
    Dmel_CG10539
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    10539; 7-10; 7084; CG10539; d-S6K; Dmel\CG10539; dp70s6k; dP70S6K; Dp70s6k; Dp70S6k; dp70[S6k]; Dp70[s6k]; dps6k; ds6k; dS6k; dS6K; DS6K; fs(3)07084; l(3)07084; p-S6K; p70 S6K; p70/S6K; p70s6K; p70S6K; p70[S6 kinase]; p70[S6kinase]; p70[S6k]; p70[S6K]; Pk64F; Pk?6; s6k; S6K; S6K1; s6k11; S6k|S6K

    Genomic context

    See S6k in Genome Data Viewer
    Location:
    64E8-64E11; 3-15 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.18 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5797549..5810931, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5790649..5804031, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Bre1 Neighboring gene Tektin C Neighboring gene uncharacterized protein Neighboring gene krishah Neighboring gene mad2 Neighboring gene vein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    • Homologs of the S6k gene: The S6k gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, A.thaliana, rice, and frog.
    • Orthologs

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    ribosomal protein S6 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribosomal protein S6 kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    larval feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell growth TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cell size IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell size TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of growth TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of multicellular organism growth TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of organ growth TAS
    Traceable Author Statement
    more info
    PubMed 
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of cell size TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of terminal button organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to nutrient TAS
    Traceable Author Statement
    more info
    PubMed 
    response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic growth at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol HDA PubMed 
    nucleoplasm HDA PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ribosomal protein S6 kinase
    Names
    CG10539-PA
    CG10539-PB
    RPS6-p70-protein kinase
    S6 kinase
    S6-kinase
    S6K kinase
    S6k-PA
    S6k-PB
    S6kinase
    dS6 kinase
    p70 S6 kinase
    p70 S6 kinase 1
    p70 ribosomal S6 kinase
    p70S6 kinase
    p70S6K kinase
    protein kinase-like 64F
    ribosomal S6 protein kinase
    NP_001261450.1
    NP_523941.2

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5797549..5810931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274521.1NP_001261450.1  ribosomal protein S6 kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261450.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q94533
      Related
      FBpp0305462, FBtr0333264
      Conserved Domains (2) summary
      PTZ00263
      Location:76397
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd05584
      Location:81402
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
    2. NM_079217.3NP_523941.2  ribosomal protein S6 kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523941.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q94533
      Related
      FBpp0076820, FBtr0077114
      Conserved Domains (2) summary
      PTZ00263
      Location:76397
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd05584
      Location:81402
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
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