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    Brwd3 bromodomain and WD repeat domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 382236, updated on 31-Jan-2019

    Summary

    Official Symbol
    Brwd3provided by MGI
    Official Full Name
    bromodomain and WD repeat domain containing 3provided by MGI
    Primary source
    MGI:MGI:3029414
    See related
    Ensembl:ENSMUSG00000063663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brodl; Gm596; Gm10452; D030064D06Rik
    Expression
    Broad expression in placenta adult (RPKM 3.9), CNS E11.5 (RPKM 1.8) and 20 other tissues See more
    Orthologs

    Genomic context

    See Brwd3 in Genome Data Viewer
    Location:
    X; X D
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (108737227..108834362, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (105937547..106029694, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene WASP family 1 pseudogene Neighboring gene syntaxin 3 pseudogene Neighboring gene RIKEN cDNA 2810403D21 gene Neighboring gene capping protein (actin filament), gelsolin-like pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    bromodomain and WD repeat-containing protein 3
    Names
    bromo domain-containing protein disrupted in leukemia

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081477.2NP_001074946.1  bromodomain and WD repeat-containing protein 3

      See identical proteins and their annotated locations for NP_001074946.1

      Status: VALIDATED

      Source sequence(s)
      AL731764, BX000698
      Consensus CDS
      CCDS41100.1
      UniProtKB/Swiss-Prot
      A2AHJ4
      Related
      ENSMUSP00000123588.1, ENSMUST00000150434.7
      Conserved Domains (5) summary
      cd05529
      Location:11281240
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      COG2319
      Location:175540
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:172494
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:183220
      7WD40; WD40 repeat [structural motif]
      cl02556
      Location:12991439
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      108737227..108834362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528114.3XP_006528177.1  bromodomain and WD repeat-containing protein 3 isoform X1

      Conserved Domains (5) summary
      cd05529
      Location:11281240
      Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
      COG2319
      Location:175540
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:172494
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:183220
      7WD40; WD40 repeat [structural motif]
      cl02556
      Location:12991439
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
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