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    Crtc1 CREB regulated transcription coactivator 1 [ Mus musculus (house mouse) ]

    Gene ID: 382056, updated on 12-May-2024

    Summary

    Official Symbol
    Crtc1provided by MGI
    Official Full Name
    CREB regulated transcription coactivator 1provided by MGI
    Primary source
    MGI:MGI:2142523
    See related
    Ensembl:ENSMUSG00000003575 AllianceGenome:MGI:2142523
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mect1; TORC1; TORC-1; mKIAA0616
    Summary
    Predicted to enable cAMP response element binding protein binding activity. Involved in entrainment of circadian clock by photoperiod and positive regulation of CREB transcription factor activity. Acts upstream of or within several processes, including energy homeostasis; memory; and negative regulation of membrane hyperpolarization. Located in cytoplasm and nucleus. Is expressed in limb and limb mesenchyme. Used to study major depressive disorder. Orthologous to human CRTC1 (CREB regulated transcription coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 24.8), cortex adult (RPKM 22.6) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Crtc1 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70835002..70892720, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70382352..70439702, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene UPF1 RNA helicase and ATPase Neighboring gene STARR-seq mESC enhancer starr_21770 Neighboring gene predicted gene, 51533 Neighboring gene cartilage oligomeric matrix protein Neighboring gene kelch-like 26 Neighboring gene STARR-positive B cell enhancer ABC_E1368 Neighboring gene transmembrane protein 59-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC90786

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cAMP response element binding protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cAMP response element binding protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in entrainment of circadian clock by photoperiod IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of membrane hyperpolarization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of CREB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of CREB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynapse to nucleus signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CREB-regulated transcription coactivator 1
    Names
    mucoepidermoid carcinoma translocated 1
    mucoepidermoid carcinoma translocated protein 1 homolog
    transducer of CREB protein 1
    transducer of regulated cAMP response element-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004062.3NP_001004062.1  CREB-regulated transcription coactivator 1 isoform 2

      See identical proteins and their annotated locations for NP_001004062.1

      Status: VALIDATED

      Source sequence(s)
      AC158553
      Consensus CDS
      CCDS40372.1
      UniProtKB/Swiss-Prot
      Q68ED7, Q6ZQ85
      Related
      ENSMUSP00000075916.6, ENSMUST00000076615.6
      Conserved Domains (3) summary
      pfam12884
      Location:666
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:148289
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:555630
      TORC_C; Transducer of regulated CREB activity, C terminus
    2. NM_001404415.1NP_001391344.1  CREB-regulated transcription coactivator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158553
    3. NM_001404416.1NP_001391345.1  CREB-regulated transcription coactivator 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158553
    4. NM_001404417.1NP_001391346.1  CREB-regulated transcription coactivator 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158553
    5. NM_001404418.1NP_001391347.1  CREB-regulated transcription coactivator 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC158553
    6. NM_001404419.1NP_001391348.1  CREB-regulated transcription coactivator 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC158553
    7. NM_001404420.1NP_001391349.1  CREB-regulated transcription coactivator 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC158553
    8. NM_001404421.1NP_001391350.1  CREB-regulated transcription coactivator 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC158553
    9. NM_001404422.1NP_001391351.1  CREB-regulated transcription coactivator 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC158553
    10. NM_001404423.1NP_001391352.1  CREB-regulated transcription coactivator 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC158553
    11. NM_001404424.1NP_001391353.1  CREB-regulated transcription coactivator 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC158553
    12. NM_001404425.1NP_001391354.1  CREB-regulated transcription coactivator 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC158553
    13. NM_001404426.1NP_001391355.1  CREB-regulated transcription coactivator 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC158553
    14. NM_001404427.1NP_001391356.1  CREB-regulated transcription coactivator 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC158553
    15. NM_001404428.1NP_001391357.1  CREB-regulated transcription coactivator 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC158553
    16. NM_001404429.1NP_001391358.1  CREB-regulated transcription coactivator 1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC158553
    17. NM_001404430.1NP_001391359.1  CREB-regulated transcription coactivator 1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC158553

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70835002..70892720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242309.4XP_011240611.1  CREB-regulated transcription coactivator 1 isoform X2

      Conserved Domains (3) summary
      pfam12884
      Location:666
      TORC_N; Transducer of regulated CREB activity, N-terminus
      pfam12885
      Location:148316
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:553628
      TORC_C; Transducer of regulated CREB activity, C-terminus
    2. XM_011242312.3XP_011240614.1  CREB-regulated transcription coactivator 1 isoform X6

      Conserved Domains (2) summary
      pfam12885
      Location:23161
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:427502
      TORC_C; Transducer of regulated CREB activity, C-terminus
    3. XM_036154147.1XP_036010040.1  CREB-regulated transcription coactivator 1 isoform X6

      Conserved Domains (2) summary
      pfam12885
      Location:23161
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:427502
      TORC_C; Transducer of regulated CREB activity, C-terminus
    4. XM_011242313.4XP_011240615.1  CREB-regulated transcription coactivator 1 isoform X7

      Conserved Domains (2) summary
      pfam12885
      Location:1157
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:423498
      TORC_C; Transducer of regulated CREB activity, C-terminus
    5. XM_011242314.4XP_011240616.1  CREB-regulated transcription coactivator 1 isoform X12

      Conserved Domains (2) summary
      pfam12884
      Location:666
      TORC_N; Transducer of regulated CREB activity, N-terminus
      pfam12885
      Location:148316
      TORC_M; Transducer of regulated CREB activity middle domain