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    Dpy19l4 dpy-19 like 4 [ Mus musculus (house mouse) ]

    Gene ID: 381510, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Dpy19l4provided by MGI
    Official Full Name
    dpy-19 like 4provided by MGI
    Primary source
    MGI:MGI:2685869
    See related
    Ensembl:ENSMUSG00000045205 AllianceGenome:MGI:2685869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Narg3; Gm1023
    Summary
    Predicted to enable mannosyltransferase activity. Predicted to be involved in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in nuclear inner membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human DPY19L4 (dpy-19 like 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 7.8), limb E14.5 (RPKM 4.2) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 A1; 4 5.11 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (11261315..11322153, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (11261315..11322138, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A630034I12 gene Neighboring gene STARR-seq mESC enhancer starr_09593 Neighboring gene STARR-seq mESC enhancer starr_09594 Neighboring gene STARR-positive B cell enhancer ABC_E9234 Neighboring gene cyclin E2 Neighboring gene integrator complex subunit 8 Neighboring gene STARR-seq mESC enhancer starr_09596 Neighboring gene epithelial splicing regulatory protein 1 Neighboring gene ES cell cis-regulatory motif 9a Neighboring gene predicted gene, 35631

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. N-methyl-D-aspartate receptors regulate a group of transiently expressed genes in the developing brain. Sugiura N, et al. J Biol Chem, 2001 Apr 27. PMID 11297529
    2. Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex. Watanabe K, et al. Development, 2011 Nov. PMID 22028030, Free PMC Article
    3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable C-mannosyltransferase DPY19L4
    Names
    NMDA receptor-regulated gene 3
    dpy-19-like protein 4
    protein dpy-19 homolog 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081201.2 → NP_001074670.1  probable C-mannosyltransferase DPY19L4

      See identical proteins and their annotated locations for NP_001074670.1

      Status: VALIDATED

      Source sequence(s)
      AL772170, AL840625, AL953845
      Consensus CDS
      CCDS38692.1
      UniProtKB/Swiss-Prot
      A2AJQ3, B2RW18, Q3T9A8
      Related
      ENSMUSP00000081954.6, ENSMUST00000084892.12
      Conserved Domains (1) summary
      pfam10034
      Location:60 → 713
      Dpy19; Q-cell neuroblast polarization

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      11261315..11322153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538041.5 → XP_006538104.1  probable C-mannosyltransferase DPY19L4 isoform X1

      Conserved Domains (1) summary
      pfam10034
      Location:1 → 652
      Dpy19; Q-cell neuroblast polarisation

    2. XM_006538042.5 → XP_006538105.1  probable C-mannosyltransferase DPY19L4 isoform X2

      UniProtKB/TrEMBL
      A2AJQ2
      Conserved Domains (1) summary
      pfam10034
      Location:1 → 456
      Dpy19; Q-cell neuroblast polarisation

    RNA

    1. XR_004941929.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AJQ3.1 GenPept UniProtKB/Swiss-Prot:A2AJQ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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