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    Kif14 kinesin family member 14 [ Mus musculus (house mouse) ]

    Gene ID: 381293, updated on 9-Sep-2018

    Summary

    Official Symbol
    Kif14provided by MGI
    Official Full Name
    kinesin family member 14provided by MGI
    Primary source
    MGI:MGI:1098226
    See related
    Ensembl:ENSMUSG00000041498 Vega:OTTMUSG00000046083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D1Ertd367e; E130203M01
    Expression
    Biased expression in liver E14 (RPKM 3.3), liver E14.5 (RPKM 2.8) and 14 other tissues See more
    Orthologs

    Genomic context

    See Kif14 in Genome Data Viewer
    Location:
    1 E4; 1 59.8 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (136466290..136555938)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (138364535..138428088)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene calmodulin regulated spectrin-associated protein family, member 2 Neighboring gene RIKEN cDNA 9230116N13 gene Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 Neighboring gene predicted gene 29485 Neighboring gene zinc finger protein 281 Neighboring gene predicted gene, 34056 Neighboring gene predicted gene, 41958

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC189899

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP-dependent microtubule motor activity, plus-end-directed IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation in forebrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellar Purkinje cell layer structural organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellar cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellar granular layer structural organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of integrin activation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    olfactory bulb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Rap protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    Flemming body ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kinesin-like protein KIF14
    Names
    N-3 kinesin
    truncated kinesin family member 14

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287179.2NP_001274108.1  kinesin-like protein KIF14

      See identical proteins and their annotated locations for NP_001274108.1

      Status: VALIDATED

      Source sequence(s)
      AB731728, AC122127, AC126606, AK087451
      Consensus CDS
      CCDS78693.1
      UniProtKB/Swiss-Prot
      L0N7N1
      Related
      ENSMUSP00000139698.1, OTTMUSP00000066663, ENSMUST00000189413.6, OTTMUST00000120321
      Conserved Domains (6) summary
      smart00129
      Location:393743
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:838935
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:392743
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:9981122
      YlqD; YlqD protein
      pfam16183
      Location:740859
      Kinesin_assoc; Kinesin-associated
      cl21478
      Location:9721038
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      136466290..136555938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248046.1XP_011246348.1  kinesin-like protein KIF14 isoform X2

      Conserved Domains (7) summary
      smart00129
      Location:393743
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:838935
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:392743
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:9981122
      YlqD; YlqD protein
      pfam15346
      Location:9801106
      ARGLU; Arginine and glutamate-rich 1
      pfam16183
      Location:740859
      Kinesin_assoc; Kinesin-associated
      cl21478
      Location:9721038
      ATP-synt_B; ATP synthase B/B' CF(0)
    2. XM_011248039.1XP_011246341.1  kinesin-like protein KIF14 isoform X1

      See identical proteins and their annotated locations for XP_011246341.1

      Conserved Domains (7) summary
      smart00129
      Location:393743
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:838935
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:392743
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:9981122
      YlqD; YlqD protein
      pfam15346
      Location:9801106
      ARGLU; Arginine and glutamate-rich 1
      pfam16183
      Location:740859
      Kinesin_assoc; Kinesin-associated
      cl21478
      Location:9721038
      ATP-synt_B; ATP synthase B/B' CF(0)
    3. XM_011248040.1XP_011246342.1  kinesin-like protein KIF14 isoform X1

      See identical proteins and their annotated locations for XP_011246342.1

      Conserved Domains (7) summary
      smart00129
      Location:393743
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:838935
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:392743
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:9981122
      YlqD; YlqD protein
      pfam15346
      Location:9801106
      ARGLU; Arginine and glutamate-rich 1
      pfam16183
      Location:740859
      Kinesin_assoc; Kinesin-associated
      cl21478
      Location:9721038
      ATP-synt_B; ATP synthase B/B' CF(0)
    4. XM_011248044.1XP_011246346.1  kinesin-like protein KIF14 isoform X1

      See identical proteins and their annotated locations for XP_011246346.1

      Conserved Domains (7) summary
      smart00129
      Location:393743
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:838935
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:392743
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:9981122
      YlqD; YlqD protein
      pfam15346
      Location:9801106
      ARGLU; Arginine and glutamate-rich 1
      pfam16183
      Location:740859
      Kinesin_assoc; Kinesin-associated
      cl21478
      Location:9721038
      ATP-synt_B; ATP synthase B/B' CF(0)
    5. XM_011248043.2XP_011246345.1  kinesin-like protein KIF14 isoform X1

      See identical proteins and their annotated locations for XP_011246345.1

      Conserved Domains (7) summary
      smart00129
      Location:393743
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:838935
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:392743
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:9981122
      YlqD; YlqD protein
      pfam15346
      Location:9801106
      ARGLU; Arginine and glutamate-rich 1
      pfam16183
      Location:740859
      Kinesin_assoc; Kinesin-associated
      cl21478
      Location:9721038
      ATP-synt_B; ATP synthase B/B' CF(0)
    6. XM_006529729.3XP_006529792.1  kinesin-like protein KIF14 isoform X3

      See identical proteins and their annotated locations for XP_006529792.1

      UniProtKB/Swiss-Prot
      L0N7N1
      Conserved Domains (6) summary
      smart00129
      Location:393743
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:838935
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:392743
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:9981122
      YlqD; YlqD protein
      pfam16183
      Location:740859
      Kinesin_assoc; Kinesin-associated
      cl21478
      Location:9721038
      ATP-synt_B; ATP synthase B/B' CF(0)
    7. XM_006529730.2XP_006529793.2  kinesin-like protein KIF14 isoform X1

      See identical proteins and their annotated locations for XP_006529793.2

      Conserved Domains (7) summary
      smart00129
      Location:393743
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:838935
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:392743
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:9981122
      YlqD; YlqD protein
      pfam15346
      Location:9801106
      ARGLU; Arginine and glutamate-rich 1
      pfam16183
      Location:740859
      Kinesin_assoc; Kinesin-associated
      cl21478
      Location:9721038
      ATP-synt_B; ATP synthase B/B' CF(0)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081258.1: Suppressed sequence

      Description
      NM_001081258.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center