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    Hjurp Holliday junction recognition protein [ Mus musculus (house mouse) ]

    Gene ID: 381280, updated on 31-Jan-2019

    Summary

    Official Symbol
    Hjurpprovided by MGI
    Official Full Name
    Holliday junction recognition proteinprovided by MGI
    Primary source
    MGI:MGI:2685821
    See related
    Ensembl:ENSMUSG00000044783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm975; Mfleg1; 6430706D22Rik; A730008H23Rik; C330011F01Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 46.1), CNS E11.5 (RPKM 40.6) and 27 other tissues See more
    Orthologs

    Genomic context

    See Hjurp in Genome Data Viewer
    Location:
    1; 1 D
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (88258856..88277633, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (90155431..90174154, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A9 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6B Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6A Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A5 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene transient receptor potential cation channel, subfamily M, member 8 Neighboring gene secreted phosphoprotein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Homology

    Clone Names

    • MGC66590

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    CENP-A containing nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    condensed chromosome kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    Holliday junction recognition protein
    Names
    fetal liver expressing gene 1 protein homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198652.2NP_941054.2  Holliday junction recognition protein

      Status: VALIDATED

      Source sequence(s)
      AC087780, AK164562, BC057309, CJ241667
      Consensus CDS
      CCDS15144.1
      UniProtKB/Swiss-Prot
      Q6PG16
      UniProtKB/TrEMBL
      E9QKG8
      Related
      ENSMUSP00000054263.8, ENSMUST00000054674.14
      Conserved Domains (3) summary
      pfam10384
      Location:1168
      Scm3; Centromere protein Scm3
      pfam12346
      Location:254370
      HJURP_mid; Holliday junction recognition protein-associated repeat
      pfam12347
      Location:386444
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      88258856..88277633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529721.3XP_006529784.1  Holliday junction recognition protein isoform X2

      UniProtKB/TrEMBL
      E9Q4T0
      Related
      ENSMUSP00000070419.5, ENSMUST00000065420.11
      Conserved Domains (3) summary
      pfam10384
      Location:1168
      Scm3; Centromere protein Scm3
      pfam12346
      Location:178294
      HJURP_mid; Holliday junction recognition protein-associated repeat
      pfam12347
      Location:310368
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
    2. XM_006529722.3XP_006529785.1  Holliday junction recognition protein isoform X3

      Conserved Domains (2) summary
      pfam12346
      Location:148264
      HJURP_mid; Holliday junction recognition protein-associated repeat
      pfam12347
      Location:280338
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
    3. XM_006529720.3XP_006529783.1  Holliday junction recognition protein isoform X1

      See identical proteins and their annotated locations for XP_006529783.1

      UniProtKB/Swiss-Prot
      Q6PG16
      Conserved Domains (3) summary
      pfam10384
      Location:1168
      Scm3; Centromere protein Scm3
      pfam12346
      Location:254353
      HJURP_mid; Holliday junction recognition protein-associated repeat
      pfam12347
      Location:369427
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
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