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    Mreg melanoregulin [ Mus musculus (house mouse) ]

    Gene ID: 381269, updated on 16-Oct-2021

    Summary

    Official Symbol
    Mregprovided by MGI
    Official Full Name
    melanoregulinprovided by MGI
    Primary source
    MGI:MGI:2151839
    See related
    Ensembl:ENSMUSG00000039395
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dsu; Wdt2; Gm974
    Expression
    Broad expression in liver adult (RPKM 12.4), placenta adult (RPKM 7.2) and 20 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mreg in Genome Data Viewer
    Location:
    1; 1 C3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (72198392..72251473, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (72159233..72212314, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (72205807..72258881, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15 pseudogene Neighboring gene predicted gene 4319 Neighboring gene predicted gene, 51630 Neighboring gene predicted gene, 25360

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Clone Names

    • MGC92980

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intrinsic component of organelle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in melanosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in melanosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in melanosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    melanoregulin
    Names
    dilute suppressor protein
    whn-dependent transcript 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005423.2NP_001005423.1  melanoregulin isoform 1

      See identical proteins and their annotated locations for NP_001005423.1

      Status: VALIDATED

      Source sequence(s)
      AY628210, BC068125
      Consensus CDS
      CCDS15032.1
      UniProtKB/Swiss-Prot
      Q6NVG5
      Related
      ENSMUSP00000041878.8, ENSMUST00000048860.9
      Conserved Domains (1) summary
      pfam15812
      Location:46191
      MREG; Melanoregulin
    2. NM_001357488.1NP_001344417.1  melanoregulin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC120136
      Conserved Domains (1) summary
      pfam15812
      Location:20165
      MREG; Melanoregulin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      72198392..72251473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496111.2XP_006496174.1  melanoregulin isoform X1

      See identical proteins and their annotated locations for XP_006496174.1

      Conserved Domains (1) summary
      pfam15812
      Location:20165
      MREG; Melanoregulin
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