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    Tbc1d22b TBC1 domain family, member 22B [ Mus musculus (house mouse) ]

    Gene ID: 381085, updated on 26-Nov-2022

    Summary

    Official Symbol
    Tbc1d22bprovided by MGI
    Official Full Name
    TBC1 domain family, member 22Bprovided by MGI
    Primary source
    MGI:MGI:2681867
    See related
    Ensembl:ENSMUSG00000042203 AllianceGenome:MGI:2681867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable 14-3-3 protein binding activity and GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Orthologous to human TBC1D22B (TBC1 domain family member 22B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 16.0), adrenal adult (RPKM 12.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tbc1d22b in Genome Data Viewer
    Location:
    17; 17 A3.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29768753..29825868)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29549768..29606895)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26885 Neighboring gene proviral integration site 1 Neighboring gene transmembrane protein 217 Neighboring gene TBC1 domain family, member 22B, opposite strand Neighboring gene microRNA 7667 Neighboring gene predicted gene, 28043 Neighboring gene ring finger protein 8 Neighboring gene predicted gene, 20161

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC31516, MGC61359

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    TBC1 domain family member 22B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414341.1NP_001401270.1  TBC1 domain family member 22B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163629
    2. NM_001414343.1NP_001401272.1  TBC1 domain family member 22B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163629
    3. NM_001414346.1NP_001401275.1  TBC1 domain family member 22B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163629
    4. NM_198647.2NP_941049.1  TBC1 domain family member 22B isoform 1

      See identical proteins and their annotated locations for NP_941049.1

      Status: VALIDATED

      Source sequence(s)
      AC163629
      Consensus CDS
      CCDS28597.1
      UniProtKB/TrEMBL
      A0A6P5NU46, Q80VE5
      Related
      ENSMUSP00000046877.8, ENSMUST00000048677.9
      Conserved Domains (1) summary
      smart00164
      Location:207457
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RNA

    1. NR_182277.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163629
    2. NR_182287.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163629

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      29768753..29825868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524488.3XP_006524551.1  TBC1 domain family member 22B isoform X1

      Conserved Domains (1) summary
      smart00164
      Location:188438
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs