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    Parl presenilin associated, rhomboid-like [ Mus musculus (house mouse) ]

    Gene ID: 381038, updated on 11-Mar-2018

    Summary

    Official Symbol
    Parlprovided by MGI
    Official Full Name
    presenilin associated, rhomboid-likeprovided by MGI
    Primary source
    MGI:MGI:1277152
    See related
    Ensembl:ENSMUSG00000033918 Vega:OTTMUSG00000025306
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Psarl; PSARL1; PRO2207; PSENIP2; D16Ertd607e
    Expression
    Ubiquitous expression in bladder adult (RPKM 19.4), testis adult (RPKM 16.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Parl in Genome Data Viewer
    Location:
    16 A3; 16 12.4 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (20279820..20302395, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (20279893..20302435, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene YEATS domain containing 2 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene Neighboring gene predicted gene, 41431 Neighboring gene MAP6 domain containing 1 Neighboring gene cytochrome P450, family 2, subfamily ab, polypeptide 1 Neighboring gene ATP-binding cassette, sub-family C (CFTR/MRP), member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteolysis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    presenilins-associated rhomboid-like protein, mitochondrial
    Names
    mitochondrial intramembrane-cleaving protease PARL
    NP_001005767.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005767.4NP_001005767.1  presenilins-associated rhomboid-like protein, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001005767.1

      Status: PROVISIONAL

      Source sequence(s)
      AC154526
      Consensus CDS
      CCDS28044.1
      UniProtKB/Swiss-Prot
      Q5XJY4
      Related
      ENSMUSP00000045361.8, OTTMUSP00000030672, ENSMUST00000048642.14, OTTMUST00000062273
      Conserved Domains (1) summary
      pfam01694
      Location:207348
      Rhomboid; Rhomboid family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      20279820..20302395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_384575.3 RNA Sequence

      Related
      ENSMUST00000136252.7, OTTMUST00000062274
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