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    Alg10b asparagine-linked glycosylation 10B (alpha-1,2-glucosyltransferase) [ Mus musculus (house mouse) ]

    Gene ID: 380959, updated on 26-Sep-2022


    Official Symbol
    Alg10bprovided by MGI
    Official Full Name
    asparagine-linked glycosylation 10B (alpha-1,2-glucosyltransferase)provided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000075470 AllianceGenome:MGI:2146159
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    nse5; Deaf1; Gm917
    Predicted to enable dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity. Acts upstream of or within auditory receptor cell development and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Used to study nonsyndromic deafness. Human ortholog(s) of this gene implicated in long QT syndrome 2. Orthologous to several human genes including ALG10B (ALG10 alpha-1,2-glucosyltransferase B). [provided by Alliance of Genome Resources, Apr 2022]
    Ubiquitous expression in whole brain E14.5 (RPKM 13.4), CNS E11.5 (RPKM 12.0) and 28 other tissues See more
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    Genomic context

    See Alg10b in Genome Data Viewer
    15; 15 E3
    Exon count:
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (90108514..90114757)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (90224311..90230554)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin X Neighboring gene predicted gene, 36330 Neighboring gene predicted gene, 24415 Neighboring gene microRNA 7648 Neighboring gene predicted gene, 36480 Neighboring gene WEE1 homolog 2 pseudogene

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (2) 

    General gene information



    • Homologs of the Alg10b gene: The Alg10b gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, A.thaliana, rice, and frog.
    • Orthologs

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    enables transferase activity ISO
    Inferred from Sequence Orthology
    more info
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info

    General protein information

    Preferred Names
    putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
    alpha-1,2-glucosyltransferase ALG10-A
    alpha-2-glucosyltransferase ALG10-B
    asparagine-linked glycosylation 10 homolog B (yeast, alpha-1,2-glucosyltransferase)
    asparagine-linked glycosylation protein 10 homolog B
    potassium channel regulator 1
    putative alpha-1,2-glucosyltransferase ALG10-B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033441.3NP_001028613.1  putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

      See identical proteins and their annotated locations for NP_001028613.1

      Status: PROVISIONAL

      Source sequence(s)
      Consensus CDS
      Q3TLS4, Q3UGP8
      ENSMUSP00000097882.2, ENSMUST00000100309.3
      Conserved Domains (1) summary
      DIE2_ALG10; DIE2/ALG10 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000081.7 Reference GRCm39 C57BL/6J

      GenBank, FASTA, Sequence Viewer (Graphics)