U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Lyrm4 LYR motif containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 380840, updated on 19-Jun-2024

    Summary

    Official Symbol
    Lyrm4provided by MGI
    Official Full Name
    LYR motif containing 4provided by MGI
    Primary source
    MGI:MGI:2683538
    See related
    Ensembl:ENSMUSG00000046573 AllianceGenome:MGI:2683538
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm903
    Summary
    Predicted to be involved in iron-sulfur cluster assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 19. Orthologous to human LYRM4 (LYR motif containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 6.6), cortex adult (RPKM 6.3) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lyrm4 in Genome Data Viewer
    Location:
    13 A3.3; 13 14.44 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (36162778..36301543, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (35978797..36117357, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34183 Neighboring gene ribonuclease P 40 subunit Neighboring gene STARR-seq mESC enhancer starr_34184 Neighboring gene protein phosphatase 1, regulatory subunit 3G Neighboring gene predicted gene, 30127 Neighboring gene transmembrane p24 trafficking protein 10, pseudogene Neighboring gene predicted gene, 18132 Neighboring gene STARR-positive B cell enhancer ABC_E7224 Neighboring gene STARR-seq mESC enhancer starr_34186 Neighboring gene phenylalanine-tRNA synthetase 2, mitochondrial Neighboring gene STARR-seq mESC enhancer starr_34187 Neighboring gene STARR-seq mESC enhancer starr_34188 Neighboring gene predicted gene, 40912 Neighboring gene STARR-seq mESC enhancer starr_34189 Neighboring gene STARR-seq mESC enhancer starr_34190 Neighboring gene STARR-seq mESC enhancer starr_34191 Neighboring gene STARR-seq mESC enhancer starr_34192 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:36458293-36458547 Neighboring gene STARR-seq mESC enhancer starr_34193 Neighboring gene high mobility group box 1-like pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC38622

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in [2Fe-2S] cluster assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of [4Fe-4S] cluster assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in iron-sulfur cluster assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of L-cysteine desulfurase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of iron-sulfur cluster assembly complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of mitochondrial [2Fe-2S] assembly complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mitochondrial [2Fe-2S] assembly complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    LYR motif-containing protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201358.3NP_958746.1  LYR motif-containing protein 4

      See identical proteins and their annotated locations for NP_958746.1

      Status: VALIDATED

      Source sequence(s)
      AC124562, AC134860
      Consensus CDS
      CCDS36633.1
      UniProtKB/Swiss-Prot
      Q8K215
      Related
      ENSMUSP00000060779.7, ENSMUST00000053265.8
      Conserved Domains (1) summary
      cd20264
      Location:876
      Complex1_LYR_LYRM4; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      36162778..36301543 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)