Format

Send to:

Choose Destination
    • Showing Current items.

    Rph3al rabphilin 3A-like (without C2 domains) [ Mus musculus (house mouse) ]

    Gene ID: 380714, updated on 18-Sep-2018

    Summary

    Official Symbol
    Rph3alprovided by MGI
    Official Full Name
    rabphilin 3A-like (without C2 domains)provided by MGI
    Primary source
    MGI:MGI:1923492
    See related
    Ensembl:ENSMUSG00000020847 Vega:OTTMUSG00000006223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Noc2; Gm1753
    Expression
    Broad expression in ovary adult (RPKM 6.6), stomach adult (RPKM 5.2) and 21 other tissues See more
    Orthologs

    Genomic context

    See Rph3al in Genome Data Viewer
    Location:
    11; 11 B5
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (75830992..75967250, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (75645660..75724528, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Neighboring gene double C2, beta Neighboring gene predicted gene 12339 Neighboring gene RIKEN cDNA 1700016K19 gene Neighboring gene refilin B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 6530413F01Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    LIM domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rab GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion-dependent exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rab effector Noc2
    Names
    no C2 domains protein
    rabphilin-3A-like protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291159.1NP_001278088.1  rab effector Noc2 isoform 2

      See identical proteins and their annotated locations for NP_001278088.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons, and uses an alternate 3'-terminal exon, compared to variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK018335, CO800159, DV653859
      Consensus CDS
      CCDS70243.1
      UniProtKB/Swiss-Prot
      Q768S4
      Related
      ENSMUSP00000021208.4, OTTMUSP00000006526, ENSMUST00000021208.10, OTTMUST00000014050
      Conserved Domains (1) summary
      cl22851
      Location:45117
      PHD_SF; PHD finger superfamily
    2. NM_029548.4NP_083824.1  rab effector Noc2 isoform 1

      See identical proteins and their annotated locations for NP_083824.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA616014, AI594476, BQ176035, BU610075, BX631599, DV651301, DV660756
      Consensus CDS
      CCDS25058.1
      UniProtKB/Swiss-Prot
      Q768S4
      Related
      ENSMUSP00000064202.4, ENSMUST00000066504.10
      Conserved Domains (1) summary
      pfam02318
      Location:45159
      FYVE_2; FYVE-type zinc finger

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      75830992..75967250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533643.1XP_006533706.1  rab effector Noc2 isoform X2

      Conserved Domains (1) summary
      cl22851
      Location:45130
      PHD_SF; PHD finger superfamily
    2. XM_006533637.1XP_006533700.1  rab effector Noc2 isoform X1

      See identical proteins and their annotated locations for XP_006533700.1

      UniProtKB/Swiss-Prot
      Q768S4
      Conserved Domains (1) summary
      pfam02318
      Location:45159
      FYVE_2; FYVE-type zinc finger
    3. XM_006533638.3XP_006533701.1  rab effector Noc2 isoform X1

      See identical proteins and their annotated locations for XP_006533701.1

      UniProtKB/Swiss-Prot
      Q768S4
      Related
      ENSMUSP00000113869.1, OTTMUSP00000006525, ENSMUST00000121287.7, OTTMUST00000014049
      Conserved Domains (1) summary
      pfam02318
      Location:45159
      FYVE_2; FYVE-type zinc finger
    4. XM_006533640.3XP_006533703.1  rab effector Noc2 isoform X1

      See identical proteins and their annotated locations for XP_006533703.1

      UniProtKB/Swiss-Prot
      Q768S4
      Conserved Domains (1) summary
      pfam02318
      Location:45159
      FYVE_2; FYVE-type zinc finger
    5. XM_006533642.3XP_006533705.1  rab effector Noc2 isoform X1

      See identical proteins and their annotated locations for XP_006533705.1

      UniProtKB/Swiss-Prot
      Q768S4
      Conserved Domains (1) summary
      pfam02318
      Location:45159
      FYVE_2; FYVE-type zinc finger
    6. XM_006533639.3XP_006533702.1  rab effector Noc2 isoform X1

      See identical proteins and their annotated locations for XP_006533702.1

      UniProtKB/Swiss-Prot
      Q768S4
      Conserved Domains (1) summary
      pfam02318
      Location:45159
      FYVE_2; FYVE-type zinc finger
    7. XM_006533641.3XP_006533704.1  rab effector Noc2 isoform X1

      See identical proteins and their annotated locations for XP_006533704.1

      UniProtKB/Swiss-Prot
      Q768S4
      Conserved Domains (1) summary
      pfam02318
      Location:45159
      FYVE_2; FYVE-type zinc finger
    8. XM_011249100.1XP_011247402.1  rab effector Noc2 isoform X3

      Conserved Domains (1) summary
      pfam02318
      Location:45159
      FYVE_2; FYVE-type zinc finger
    9. XM_011249101.1XP_011247403.1  rab effector Noc2 isoform X4

      See identical proteins and their annotated locations for XP_011247403.1

      UniProtKB/Swiss-Prot
      Q768S4
      Conserved Domains (1) summary
      cl22851
      Location:45117
      PHD_SF; PHD finger superfamily
    10. XM_011249102.1XP_011247404.1  rab effector Noc2 isoform X4

      See identical proteins and their annotated locations for XP_011247404.1

      UniProtKB/Swiss-Prot
      Q768S4
      Related
      ENSMUSP00000104058.2, OTTMUSP00000006527, ENSMUST00000108420.8, OTTMUST00000014051
      Conserved Domains (1) summary
      cl22851
      Location:45117
      PHD_SF; PHD finger superfamily

    RNA

    1. XR_388486.1 RNA Sequence

    Support Center