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    Intu inturned planar cell polarity protein [ Mus musculus (house mouse) ]

    Gene ID: 380614, updated on 8-Dec-2018

    Summary

    Official Symbol
    Intuprovided by MGI
    Official Full Name
    inturned planar cell polarity proteinprovided by MGI
    Primary source
    MGI:MGI:2443752
    See related
    Ensembl:ENSMUSG00000060798
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pdzd6; Pdzk6; mKIAA1284; 9230116I04Rik; 9430087H23Rik
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Broad expression in heart adult (RPKM 2.7), CNS E11.5 (RPKM 2.3) and 26 other tissues See more
    Orthologs

    Genomic context

    See Intu in Genome Data Viewer
    Location:
    3; 3 B
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (40531291..40704776)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (40457623..40508662)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700017G19 gene Neighboring gene predicted gene, 46801 Neighboring gene predicted gene, 46800 Neighboring gene solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 Neighboring gene heat shock protein 4 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digit morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of planar polarity IEA
    Inferred from Electronic Annotation
    more info
     
    hair follicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    limb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spinal cord dorsal/ventral patterning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    motile cilium ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein inturned
    Names
    PDZ domain-containing protein 6
    inturned planar cell polarity effector homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175515.5NP_780724.3  protein inturned

      See identical proteins and their annotated locations for NP_780724.3

      Status: VALIDATED

      Source sequence(s)
      AC146980, BC125523, BY720518
      Consensus CDS
      CCDS84619.1
      UniProtKB/Swiss-Prot
      Q059U7
      Related
      ENSMUSP00000088725.3, ENSMUST00000091186.6
      Conserved Domains (1) summary
      cd00136
      Location:203266
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      40531291..40704776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319627.1XP_017175116.1  protein inturned isoform X1

    2. XM_017319628.1XP_017175117.1  protein inturned isoform X2

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