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    NaCP60E Na channel protein 60E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37981, updated on 27-Mar-2024

    Summary

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    Official Symbol
    NaCP60Eprovided by FlyBase
    Official Full Name
    Na channel protein 60Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085434
    Locus tag
    Dmel_CG34405
    See related
    AllianceGenome:FB:FBgn0085434
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18506; CG34405; CG9071; CT24831; DIC60; Dmel\CG34405; dsc; DSC; dsc1; DSC1; DSCI; Na-CP; smi60E
    Old locus tag
    CG18506; CG9071; Dmel_CG18506; Dmel_CG9071
    Summary
    Enables voltage-gated cation channel activity. Involved in olfactory behavior. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Is expressed in several structures, including adult central nervous system; anterior-posterior subdivision of organism; neuron projection bundle; region of integument; and spermatozoon. Human ortholog(s) of this gene implicated in benign familial neonatal epilepsy and developmental and epileptic encephalopathy 13. Orthologous to human SCN8A (sodium voltage-gated channel alpha subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    60E5-60E5; 2-107 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24891614..24921677)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20779137..20809200)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43466 Neighboring gene Na,K-ATPase Interacting Neighboring gene Ance-5 Neighboring gene uncharacterized protein Neighboring gene Thiamine pyrophosphate carrier protein 2 Neighboring gene Ribosomal protein L41 Neighboring gene painless Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels. Dong K, et al. Pestic Biochem Physiol, 2015 May. PMID 25987218
    2. Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids. Rinkevich FD, et al. Neurotoxicology, 2015 Mar. PMID 25687544, Free PMC Article
    3. Nucleotide sequence of the putative sodium channel gene from Drosophila: the four homologous domains. Salkoff L, et al. Nucleic Acids Res, 1987 Oct 26. PMID 2444928, Free PMC Article
    4. DSC1 channel-dependent developmental regulation of pyrethroid susceptibility in Drosophila melanogaster. Chen X, et al. Pestic Biochem Physiol, 2018 Jun. PMID 29891372
    5. Molecular characterization and functional expression of the DSC1 channel. Zhang T, et al. Insect Biochem Mol Biol, 2011 Jul. PMID 21571069, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We summarize major findings from recent studies and highlight a unique role of the DSC1 channel, distinct from that of the sodium channel, in regulating membrane excitability and modulating toxicity of pyrethroid insecticides
      Title: The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels.
    2. These results reveal an important role of the DSC1 channel in modulating the stability of neural circuits, particularly under environmental stresses, likely by maintaining the sustainability of synaptic transmission.
      Title: Role of the DSC1 channel in regulating neuronal excitability in Drosophila melanogaster: extending nervous system stability under stress.
    3. This study showed that transcripts lacking all cytoplasmic alternatively spliced exons still produce functional channels'
      Title: Alternative splicing in the voltage-gated sodium channel DmNav regulates activation, inactivation, and persistent current.
    4. DSC1 channels are expressed in both the central and the peripheral nervous system of adult Drosophila melanogaster.
      Title: DSC1 channels are expressed in both the central and the peripheral nervous system of adult Drosophila melanogaster.
    5. These results identify nebula/DSCR1 as a regulator of mitochondrial function and integrity and further suggest that an increased level of DSCR1 may contribute to the mitochondrial dysfunction seen in Down syndrome.
      Title: Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 24919232-24919276 mobile_element_type = transposon:1360{}5042

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables voltage-gated sodium channel activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in membrane depolarization during action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuronal action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of voltage-gated sodium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated sodium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Na channel protein 60E
    Names
    CG34405-PG
    CG34405-PH
    CG34405-PI
    CG34405-PJ
    CG34405-PK
    CG34405-PL
    CG34405-PM
    CG34405-PN
    CG34405-PO
    CG34405-PP
    Na-channel-protein
    NaCP60E-PG
    NaCP60E-PH
    NaCP60E-PI
    NaCP60E-PJ
    NaCP60E-PK
    NaCP60E-PL
    NaCP60E-PM
    NaCP60E-PN
    NaCP60E-PO
    NaCP60E-PP
    put. sodium channel gene
    smell impaired 60E
    sodium channel 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24891614..24921677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259579.3 → NP_001246508.1  Na channel protein 60E, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246508.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K814
      Conserved Domains (3) summary
      cd13433
      Location:2009 → 2063
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1768 → 2019
      Ion_trans; Ion transport protein
      pfam16905
      Location:2331 → 2386
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    2. NM_166696.5 → NP_726495.3  Na channel protein 60E, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726495.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4KF50, A9NIV8, Q27930, Q7JN09, Q7JN86, Q7JN87, Q7JN88, Q7JN89, Q7K324, Q8MMC7, Q9W0Y8
      Conserved Domains (4) summary
      cd13433
      Location:2009 → 2063
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1751 → 2019
      Ion_trans; Ion transport protein
      pfam16905
      Location:2325 → 2386
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl25732
      Location:1152 → 1421
      SMC_N; RecF/RecN/SMC N terminal domain

    3. NM_001259581.2 → NP_001246510.1  Na channel protein 60E, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246510.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7I8
      Conserved Domains (3) summary
      cd13433
      Location:2009 → 2063
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1768 → 2019
      Ion_trans; Ion transport protein
      pfam16905
      Location:2331 → 2386
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    4. NM_001274245.2 → NP_001261174.1  Na channel protein 60E, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261174.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG05, D6W4K7
      Conserved Domains (1) summary
      pfam00520
      Location:152 → 361
      Ion_trans; Ion transport protein

    5. NM_001274244.2 → NP_001261173.1  Na channel protein 60E, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261173.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGE9
      Conserved Domains (1) summary
      pfam00520
      Location:705 → 902
      Ion_trans; Ion transport protein

    6. NM_001259580.2 → NP_001246509.1  Na channel protein 60E, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246509.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K887
      Conserved Domains (3) summary
      cd13433
      Location:2014 → 2068
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1773 → 2024
      Ion_trans; Ion transport protein
      pfam16905
      Location:2336 → 2391
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    7. NM_001274246.2 → NP_001261175.1  Na channel protein 60E, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261175.1

      Status: REVIEWED

      Conserved Domains (2) summary
      cd13433
      Location:2009 → 2063
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1768 → 2019
      Ion_trans; Ion transport protein

    8. NM_001274243.2 → NP_001261172.1  Na channel protein 60E, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261172.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFH8
      Conserved Domains (3) summary
      cd13433
      Location:2009 → 2063
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1768 → 2019
      Ion_trans; Ion transport protein
      pfam16905
      Location:2331 → 2386
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    9. NM_001202078.3 → NP_001189007.2  Na channel protein 60E, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189007.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4KF50, A9NIV8, Q27930, Q7JN09, Q7JN86, Q7JN87, Q7JN88, Q7JN89, Q7K324, Q8MMC7, Q9W0Y8
      Conserved Domains (4) summary
      cd13433
      Location:2009 → 2063
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1751 → 2019
      Ion_trans; Ion transport protein
      pfam16905
      Location:2325 → 2386
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl25732
      Location:1152 → 1421
      SMC_N; RecF/RecN/SMC N terminal domain

    10. NM_001259578.1 → NP_001246507.1  Na channel protein 60E, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246507.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K8B5
      Conserved Domains (3) summary
      cd13433
      Location:1877 → 1931
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1636 → 1887
      Ion_trans; Ion transport protein
      pfam16905
      Location:2199 → 2254
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7I8 A0A0B4K7I8
    A0A0B4K814 A0A0B4K814
    A0A0B4K887 A0A0B4K887
    A0A0B4K8B5 A0A0B4K8B5
    A0A0B4KFH8 A0A0B4KFH8
    A0A0B4KG05 A0A0B4KG05
    A0A0B4KGE9 A0A0B4KGE9
    Q9W0Y8.6 Q9W0Y8

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