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    KIF3C kinesin family member 3C [ Homo sapiens (human) ]

    Gene ID: 3797, updated on 3-Apr-2024

    Summary

    Official Symbol
    KIF3Cprovided by HGNC
    Official Full Name
    kinesin family member 3Cprovided by HGNC
    Primary source
    HGNC:HGNC:6321
    See related
    Ensembl:ENSG00000084731 MIM:602845; AllianceGenome:HGNC:6321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable microtubule binding activity and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to act upstream of or within organelle transport along microtubule. Predicted to be located in microtubule cytoskeleton; neuronal cell body; and neuronal ribonucleoprotein granule. Predicted to be part of kinesin complex. Predicted to be active in microtubule. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 57.3), adrenal (RPKM 4.3) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    Location:
    2p23.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (25926598..25982497, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (25961945..26017861, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (26149467..26205366, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ASXL transcriptional regulator 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15465 Neighboring gene Sharpr-MPRA regulatory region 10168 Neighboring gene prostaglandin E synthase 3 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26083605-26084105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11264 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26202609-26203118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26203119-26203627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:26204137-26204645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:26204646-26205155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11267 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26234163-26234664 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26234665-26235164 Neighboring gene ubiquinol-cytochrome c reductase hinge protein pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26251416-26251944 Neighboring gene tRNA methyltransferase subunit 11-2 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of kinesin family member 3C (KIF3C) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytoskeletal motor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in ciliary tip TAS
    Traceable Author Statement
    more info
     
    located_in cilium TAS
    Traceable Author Statement
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    kinesin-like protein KIF3C
    Names
    KIF3C variant protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002254.8NP_002245.4  kinesin-like protein KIF3C

      See identical proteins and their annotated locations for NP_002245.4

      Status: VALIDATED

      Source sequence(s)
      AC013449, AC064847, KF456639
      Consensus CDS
      CCDS1719.1
      UniProtKB/Swiss-Prot
      O14782, O43544, Q4ZG18, Q53SX5, Q562F7
      UniProtKB/TrEMBL
      A2RU78, B7ZM25, Q7Z2W5
      Related
      ENSP00000264712.3, ENST00000264712.8
      Conserved Domains (4) summary
      cd01371
      Location:9365
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
      pfam00225
      Location:16365
      Kinesin; Kinesin motor domain
      cd16269
      Location:538549
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:461569
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      25926598..25982497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264299.4XP_005264356.2  kinesin-like protein KIF3C isoform X1

      UniProtKB/TrEMBL
      B7ZM25
      Conserved Domains (4) summary
      cd01371
      Location:9365
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
      pfam00225
      Location:16365
      Kinesin; Kinesin motor domain
      cd16269
      Location:538549
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:461569
      GBP_C; Guanylate-binding protein, C-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      25961945..26017861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341956.1XP_054197931.1  kinesin-like protein KIF3C isoform X1