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    KCNS2 potassium voltage-gated channel modifier subfamily S member 2 [ Homo sapiens (human) ]

    Gene ID: 3788, updated on 11-Apr-2024

    Summary

    Official Symbol
    KCNS2provided by HGNC
    Official Full Name
    potassium voltage-gated channel modifier subfamily S member 2provided by HGNC
    Primary source
    HGNC:HGNC:6301
    See related
    Ensembl:ENSG00000156486 MIM:602906; AllianceGenome:HGNC:6301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KV9.2
    Summary
    Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of delayed rectifier potassium channel activity. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 4.8), urinary bladder (RPKM 1.1) and 8 other tissues See more
    Orthologs
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    Genomic context

    Location:
    8q22.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (98426958..98432853)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (99552416..99558311)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (99439186..99445081)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 3 Neighboring gene WASH complex subunit 3 pseudogene Neighboring gene VISTA enhancer hs908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99434278-99434886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19397 Neighboring gene microRNA 9903 Neighboring gene RNA, U6 small nuclear 748, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:99601941-99603140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27679 Neighboring gene ATP5PF pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of delayed rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily S member 2
    Names
    delayed-rectifier K(+) channel alpha subunit 2
    potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
    voltage-gated potassium channel subunit Kv9.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020697.4NP_065748.1  potassium voltage-gated channel subfamily S member 2

      See identical proteins and their annotated locations for NP_065748.1

      Status: VALIDATED

      Source sequence(s)
      AB032970, AP003355, BC034778, BI819243
      Consensus CDS
      CCDS6279.1
      UniProtKB/Swiss-Prot
      A8KAN1, Q9ULS6
      Related
      ENSP00000287042.4, ENST00000287042.5
      Conserved Domains (2) summary
      pfam00520
      Location:186421
      Ion_trans; Ion transport protein
      pfam02214
      Location:19118
      BTB_2; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      98426958..98432853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      99552416..99558311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)