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    KCNN4 potassium calcium-activated channel subfamily N member 4 [ Homo sapiens (human) ]

    Gene ID: 3783, updated on 8-Jul-2021

    Summary

    Official Symbol
    KCNN4provided by HGNC
    Official Full Name
    potassium calcium-activated channel subfamily N member 4provided by HGNC
    Primary source
    HGNC:HGNC:6293
    See related
    Ensembl:ENSG00000104783 MIM:602754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IK; IK1; SK4; DHS2; KCA4; hSK4; IKCA1; hKCa4; KCa3.1; hIKCa1
    Summary
    The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in salivary gland (RPKM 25.8), stomach (RPKM 13.6) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See KCNN4 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (43766533..43782139, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44270685..44285125, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene immunity related GTPase cinema Neighboring gene SMG9 nonsense mediated mRNA decay factor Neighboring gene CRISPRi-validated cis-regulatory element chr19.4589 Neighboring gene Sharpr-MPRA regulatory region 14970

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Dehydrated hereditary stomatocytosis 2
    MedGen: C4225242 OMIM: 616689 GeneReviews: Not available
    Compare labs
    Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Intermediate conductance calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium-activated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables potassium channel activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small conductance calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell volume homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phospholipid translocation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of potassium ion transmembrane transport TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in potassium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in saliva secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stabilization of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated potassium channel complex IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    intermediate conductance calcium-activated potassium channel protein 4
    Names
    SKCa 4
    SKCa4
    intermediate-conductance Ca2+-activated K+ channel, KCa3.1
    potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
    putative Gardos channel
    putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel
    small conductance calcium-activated potassium channel 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052672.1 RefSeqGene

      Range
      6167..20607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1305

    mRNA and Protein(s)

    1. NM_002250.3NP_002241.1  intermediate conductance calcium-activated potassium channel protein 4

      See identical proteins and their annotated locations for NP_002241.1

      Status: REVIEWED

      Source sequence(s)
      AF022797, AF033021
      Consensus CDS
      CCDS12630.1
      UniProtKB/Swiss-Prot
      O15554
      Related
      ENSP00000496939.1, ENST00000648319.1
      Conserved Domains (3) summary
      smart01053
      Location:304376
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:15122
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:237290
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      43766533..43782139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258882.2XP_005258939.1  intermediate conductance calcium-activated potassium channel protein 4 isoform X1

      Conserved Domains (3) summary
      smart01053
      Location:272344
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:1590
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:205258
      Ion_trans_2; Ion channel
    2. XM_005258883.2XP_005258940.1  intermediate conductance calcium-activated potassium channel protein 4 isoform X2

      Related
      ENSP00000485014.1, ENST00000615047.4
      Conserved Domains (2) summary
      smart01053
      Location:241313
      CaMBD; Calmodulin binding domain
      pfam07885
      Location:174227
      Ion_trans_2; Ion channel

    RNA

    1. XR_935823.1 RNA Sequence

    2. XR_002958313.1 RNA Sequence

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