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    CA13 carbonic anhydrase 13 [ Homo sapiens (human) ]

    Gene ID: 377677, updated on 5-Mar-2024

    Summary

    Official Symbol
    CA13provided by HGNC
    Official Full Name
    carbonic anhydrase 13provided by HGNC
    Primary source
    HGNC:HGNC:14914
    See related
    Ensembl:ENSG00000185015 MIM:611436; AllianceGenome:HGNC:14914
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAXIII
    Summary
    Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be located in intracellular membrane-bounded organelle and myelin sheath. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in small intestine (RPKM 7.8), duodenum (RPKM 6.3) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    8q21.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (85245458..85284073)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (85684055..85722800)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (86157687..86196302)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:86132079-86132850 Neighboring gene uncharacterized LOC124901969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27593 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:86133623-86134392 Neighboring gene uncharacterized LOC105375936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:86138147-86138646 Neighboring gene ribosomal biogenesis factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27594 Neighboring gene NANOG hESC enhancer GRCh37_chr8:86229148-86229679 Neighboring gene uncharacterized LOC124901970 Neighboring gene carbonic anhydrase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19337 Neighboring gene CA1 upstream erythroid promoter Neighboring gene NANOG hESC enhancer GRCh37_chr8:86316751-86317252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:86350401-86350924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:86350925-86351447 Neighboring gene CA3 antisense RNA 1 Neighboring gene carbonic anhydrase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: CA3

    Clone Names

    • FLJ36434, FLJ37995, MGC59868

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in one-carbon metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    carbonic anhydrase 13
    Names
    CA-XIII
    carbonate dehydratase XIII
    carbonic anhydrase XIII
    NP_940986.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198584.3NP_940986.1  carbonic anhydrase 13

      See identical proteins and their annotated locations for NP_940986.1

      Status: VALIDATED

      Source sequence(s)
      AC011773, AK095314, BC052602, DB287770
      Consensus CDS
      CCDS6236.1
      UniProtKB/Swiss-Prot
      Q8N1Q1
      Related
      ENSP00000318912.3, ENST00000321764.4
      Conserved Domains (1) summary
      cd03119
      Location:2261
      alpha_CA_I_II_III_XIII; Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      85245458..85284073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      85684055..85722800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)