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    NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 [ Homo sapiens (human) ]

    Gene ID: 374383, updated on 5-Mar-2024

    Summary

    Official Symbol
    NCR3LG1provided by HGNC
    Official Full Name
    natural killer cell cytotoxicity receptor 3 ligand 1provided by HGNC
    Primary source
    HGNC:HGNC:42400
    See related
    Ensembl:ENSG00000188211 MIM:613714; AllianceGenome:HGNC:42400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B7H6; B7-H6; DKFZp686O24166
    Summary
    B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]
    Expression
    Broad expression in colon (RPKM 2.1), duodenum (RPKM 1.9) and 21 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    11p15.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (17351800..17381661)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (17449460..17474942)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (17373347..17398888)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3183 Neighboring gene nucleobindin 2 Neighboring gene uncharacterized LOC124902640 Neighboring gene uncharacterized LOC105376576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:17373285-17373886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:17373887-17374488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4488 Neighboring gene MPRA-validated peak1220 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr11:17397887-17398425 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:17399732-17400931 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:17408081-17408734 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:17408735-17409388 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3185 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3186 Neighboring gene Sharpr-MPRA regulatory region 5134 Neighboring gene potassium inwardly rectifying channel subfamily J member 11 Neighboring gene VISTA enhancer hs1977 Neighboring gene ATP binding cassette subfamily C member 8 Neighboring gene succinate dehydrogenase complex subunit C pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of NCR3LG1 PubMed
    Knockdown of B7 homolog 6 (B7H6; DKFZp686O24166) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp686I21167

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables immunoglobulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of immunoglobulin complex, circulating IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    natural cytotoxicity triggering receptor 3 ligand 1
    Names
    B7 homolog 6
    putative Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202439.3NP_001189368.1  natural cytotoxicity triggering receptor 3 ligand 1 precursor

      See identical proteins and their annotated locations for NP_001189368.1

      Status: VALIDATED

      Source sequence(s)
      AC124798, KC877395
      Consensus CDS
      CCDS55748.1
      UniProtKB/Swiss-Prot
      Q68D85, Q7Z3M6
      Related
      ENSP00000341637.4, ENST00000338965.9
      Conserved Domains (2) summary
      pfam01140
      Location:296377
      Gag_MA; Matrix protein (MA), p15
      cl11960
      Location:105240
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      17351800..17381661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426906.1XP_047282862.1  natural cytotoxicity triggering receptor 3 ligand 1 isoform X1

      UniProtKB/Swiss-Prot
      Q68D85, Q7Z3M6
    2. XM_011520074.4XP_011518376.1  natural cytotoxicity triggering receptor 3 ligand 1 isoform X2

      See identical proteins and their annotated locations for XP_011518376.1

      Conserved Domains (3) summary
      smart00410
      Location:5110
      IG_like; Immunoglobulin like
      pfam01140
      Location:267348
      Gag_MA; Matrix protein (MA), p15
      cl11960
      Location:76211
      Ig; Immunoglobulin domain
    3. XM_011520075.4XP_011518377.1  natural cytotoxicity triggering receptor 3 ligand 1 isoform X2

      See identical proteins and their annotated locations for XP_011518377.1

      Conserved Domains (3) summary
      smart00410
      Location:5110
      IG_like; Immunoglobulin like
      pfam01140
      Location:267348
      Gag_MA; Matrix protein (MA), p15
      cl11960
      Location:76211
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      17449460..17474942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001009913.1: Suppressed sequence

      Description
      NM_001009913.1: This RefSeq was permanently suppressed because it is mostly repetitive sequence.
    2. NR_026750.1: Suppressed sequence

      Description
      NR_026750.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.