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    NHLRC2 NHL repeat containing 2 [ Homo sapiens (human) ]

    Gene ID: 374354, updated on 8-Jul-2021

    Summary

    Official Symbol
    NHLRC2provided by HGNC
    Official Full Name
    NHL repeat containing 2provided by HGNC
    Primary source
    HGNC:HGNC:24731
    See related
    Ensembl:ENSG00000196865 MIM:618277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FINCA
    Expression
    Ubiquitous expression in heart (RPKM 7.9), thyroid (RPKM 6.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NHLRC2 in Genome Data Viewer
    Location:
    10q25.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (113854634..113917194)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (115614420..115676953)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing S1 Neighboring gene microRNA 4483 Neighboring gene uncharacterized LOC107984271 Neighboring gene DNA cross-link repair 1A Neighboring gene uncharacterized LOC105378492 Neighboring gene uncharacterized LOC105378493

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20147, FLJ25621, FLJ33312, MGC45492, DKFZp779F115

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    NHL repeat-containing protein 2
    Names
    1200003G01Rik
    novel NHL repeat domain containing protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198514.4NP_940916.2  NHL repeat-containing protein 2

      See identical proteins and their annotated locations for NP_940916.2

      Status: VALIDATED

      Source sequence(s)
      AK090631, AK098487, AL162407, AL832090, BX538287
      Consensus CDS
      CCDS7585.1
      UniProtKB/Swiss-Prot
      Q8NBF2
      UniProtKB/TrEMBL
      Q7Z658
      Related
      ENSP00000358307.3, ENST00000369301.3
      Conserved Domains (2) summary
      cd03012
      Location:55182
      TlpA_like_DipZ_like; TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA ...
      cd14951
      Location:261624
      NHL-2_like; NHL repeat domain of NHL repeat-containing protein 2 and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      113854634..113917194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539769.3XP_011538071.1  NHL repeat-containing protein 2 isoform X1

      Conserved Domains (4) summary
      cd03012
      Location:55182
      TlpA_like_DipZ_like; TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA ...
      cd05819
      Location:226263
      NHL; NHL repeat [structural motif]
      cd14951
      Location:261624
      NHL-2_like; NHL repeat domain of NHL repeat-containing protein 2 and similar proteins
      cl18310
      Location:165316
      NHL; NHL repeat unit of beta-propeller proteins
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