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    Oseg6 Outer segment 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37245, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Oseg6provided by FlyBase
    Official Full Name
    Outer segment 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0034452
    Locus tag
    Dmel_CG11237
    See related
    AllianceGenome:FB:FBgn0034452
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11237; Dmel\CG11237; IFT144; OSEG; oseg6; OSEG6; Wdr19; WDR19
    Summary
    Involved in cilium assembly. Located in non-motile cilium. Is expressed in antenno-maxillary complex; chordotonal neurons; and eo neurons. Human ortholog(s) of this gene implicated in several diseases, including Caroli disease; Senior-Loken syndrome; asphyxiating thoracic dystrophy 5; cranioectodermal dysplasia 4; and nephronophthisis 13. Orthologous to human WDR19 (WD repeat domain 19). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Oseg6 in Genome Data Viewer
    Location:
    56D12-56D13; 2-89 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19487046..19491846, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15374551..15379351, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene meiotic W68 Neighboring gene par-1 Neighboring gene Tubulin-binding cofactor B Neighboring gene Rab escort protein Neighboring gene hippo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel tools to unravel molecular mechanisms in cilia-related disorders. Fliegauf M, et al. Trends Genet, 2006 May. PMID 16564109
    2. Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium. Jékely G, et al. Bioessays, 2006 Feb. PMID 16435301
    3. Drosophila Ovarian Germline Stem Cell Cytocensor Projections Dynamically Receive and Attenuate BMP Signaling. Wilcockson SG, et al. Dev Cell, 2019 Aug 5. PMID 31178401, Free PMC Article
    4. Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo. Gogia N, et al. Neurobiol Dis, 2020 Jul. PMID 32199908, Free PMC Article
    5. Evolution of modular intraflagellar transport from a coatomer-like progenitor. van Dam TJ, et al. Proc Natl Acad Sci U S A, 2013 Apr 23. PMID 23569277, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in intraciliary retrograde transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary retrograde transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in non-motile cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle A IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle A ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    outer segment 6
    Names
    CG11237-PA
    Oseg6-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19487046..19491846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137582.3 → NP_611426.1  outer segment 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611426.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBM3
      Related
      FBpp0085689
      Conserved Domains (4) summary
      COG2319
      Location:2 → 370
      WD40; WD40 repeat [General function prediction only]
      pfam15911
      Location:515 → 571
      WD40_3; WD domain, G-beta repeat
      sd00039
      Location:56 → 97
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:53 → 344
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZBM3 A1ZBM3
    Q8MZ45 Q8MZ45

    Gene LinkOut

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