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    ITK IL2 inducible T cell kinase [ Homo sapiens (human) ]

    Gene ID: 3702, updated on 8-Jul-2021

    Summary

    Official Symbol
    ITKprovided by HGNC
    Official Full Name
    IL2 inducible T cell kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:6171
    See related
    Ensembl:ENSG00000113263 MIM:186973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EMT; LYK; LPFS1; PSCTK2
    Summary
    This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in lymph node (RPKM 23.9), appendix (RPKM 14.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ITK in Genome Data Viewer
    Location:
    5q33.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (157180840..157255185)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (156607851..156682195)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 7 Neighboring gene family with sequence similarity 71 member B Neighboring gene cytoplasmic FMR1 interacting protein 2 Neighboring gene fibronectin type III domain containing 9 Neighboring gene NIPAL4 divergent transcript Neighboring gene ribosomal protein L26 pseudogene 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study of personality traits in bipolar patients.
    GeneReviews: Not available
    Lymphoproliferative syndrome 1
    MedGen: C3552634 OMIM: 613011 GeneReviews: Not available
    Compare labs

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Inducible T-cell kinase (ITK) affects viral entry and gp120-induced actin reorganization, but does not affect HIV-1 reverse transcription or proviral DNA integration PubMed
    Nef nef HIV-1 Nef alleles from representative M-group HIV-1 subtypes can interact with ITK. Selective ITK inhibitor blocks HIV-1 infectivity and replication in a Nef-dependent manner PubMed
    nef A cell-based bimolecular fluorescence complementation assay demonstrates that HIV-1 Nef interacts with the Tec family members Bmx, Btk, and Itk, but not with Tec or Txk in 293T cells PubMed
    Pr55(Gag) gag Tec kinase chemical inhibitors diminish the recruitment of ITK to the plasma membrane perturbing HIV-1 Gag-ITK co-localization, disrupting F-actin polymerization, and inhibiting HIV-1 release and replication PubMed
    gag HIV-1 Gag, ITK, and F-actin are located in overlapping and discrete regions of T cell-T cell contact sites PubMed
    gag HIV-1 Gag and ITK are present at regions that contain cholera toxin B in HIV-1 infected T cells, indicating that Gag and ITK co-localize in lipid raft microdomains PubMed
    gag HIV-1 Gag co-localizes with IL2-inducible T-cell kinase (ITK) at the plasma membrane of transfected HEK293T cells and HIV-1 infected T cells PubMed
    gag ITK is required for efficient transcription from the HIV-1 LTR, induces a modest increase in Gag expression, and enhances virion production PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC126257, MGC126258

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in NK T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in T cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in activation of phospholipase C activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in adaptive immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in gamma-delta T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase ITK/TSK
    Names
    IL-2-inducible T-cell kinase
    T-cell-specific kinase
    homolog of mouse T-cell itk/tsk
    interleukin-2-inducible T-cell kinase
    kinase EMT
    tyrosine-protein kinase LYK
    NP_005537.3
    XP_016864932.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016276.1 RefSeqGene

      Range
      5001..79203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_189

    mRNA and Protein(s)

    1. NM_005546.4NP_005537.3  tyrosine-protein kinase ITK/TSK

      See identical proteins and their annotated locations for NP_005537.3

      Status: REVIEWED

      Source sequence(s)
      AC010609, BX538196, D13720, DB150488
      Consensus CDS
      CCDS4336.1
      UniProtKB/Swiss-Prot
      Q08881
      Related
      ENSP00000398655.4, ENST00000422843.8
      Conserved Domains (4) summary
      cd05112
      Location:358613
      PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
      cd10396
      Location:232340
      SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
      cd11908
      Location:174229
      SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
      cd01238
      Location:7148
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      157180840..157255185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009443.1XP_016864932.1  tyrosine-protein kinase ITK/TSK isoform X1

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