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    ARAF A-Raf proto-oncogene, serine/threonine kinase [ Homo sapiens (human) ]

    Gene ID: 369, updated on 6-Sep-2020

    Summary

    Official Symbol
    ARAFprovided by HGNC
    Official Full Name
    A-Raf proto-oncogene, serine/threonine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:646
    See related
    Ensembl:ENSG00000078061 MIM:311010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKS2; A-RAF; ARAF1; RAFA1
    Summary
    This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in bone marrow (RPKM 16.5), spleen (RPKM 14.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See ARAF in Genome Data Viewer
    Location:
    Xp11.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20200815 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (47561205..47571908)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47420499..47431320)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 41 Neighboring gene long intergenic non-protein coding RNA 1560 Neighboring gene NUS1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 4668 Neighboring gene synapsin I Neighboring gene TIMP metallopeptidase inhibitor 1 Neighboring gene microRNA 4769

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with ARAF PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase A-Raf
    Names
    A-Raf proto-oncogene serine/threonine-protein kinase
    Oncogene ARAF1
    Ras-binding protein DA-Raf
    proto-oncogene A-Raf-1
    proto-oncogene Pks
    v-raf murine sarcoma 3611 viral oncogene homolog 1
    v-raf murine sarcoma 3611 viral oncogene-like protein
    NP_001243125.1
    NP_001243126.1
    NP_001645.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016339.2 RefSeqGene

      Range
      5089..15792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256196.2NP_001243125.1  serine/threonine-protein kinase A-Raf isoform 2

      See identical proteins and their annotated locations for NP_001243125.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (2) is 3 aa longer than isoform 1.
      Source sequence(s)
      BC002466, BC007514, DC362427
      Consensus CDS
      CCDS75970.1
      UniProtKB/Swiss-Prot
      P10398
      UniProtKB/TrEMBL
      Q96II5
      Related
      ENSP00000290277.7, ENST00000290277.10
      Conserved Domains (3) summary
      cd01816
      Location:2091
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14150
      Location:312576
      STKc_A-Raf; Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:99146
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    2. NM_001256197.2NP_001243126.1  serine/threonine-protein kinase A-Raf isoform 3

      See identical proteins and their annotated locations for NP_001243126.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in an immediate translation termination and a novel 3' UTR compared to variant 1. The resulting isoform (3) has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AB158254, CA424869, DC362427
      Consensus CDS
      CCDS59164.1
      UniProtKB/Swiss-Prot
      P10398
      Related
      ENSP00000366238.1, ENST00000377039.2
      Conserved Domains (2) summary
      cd01816
      Location:2091
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      pfam00130
      Location:99146
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    3. NM_001654.5NP_001645.1  serine/threonine-protein kinase A-Raf isoform 1

      See identical proteins and their annotated locations for NP_001645.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1).
      Source sequence(s)
      BC002466, DC362427
      Consensus CDS
      CCDS35232.1
      UniProtKB/Swiss-Prot
      P10398
      UniProtKB/TrEMBL
      A0A024R178
      Related
      ENSP00000366244.4, ENST00000377045.9
      Conserved Domains (3) summary
      cd01816
      Location:2091
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14150
      Location:309573
      STKc_A-Raf; Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:99146
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      47561205..47571908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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