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    ITGA3 integrin subunit alpha 3 [ Homo sapiens (human) ]

    Gene ID: 3675, updated on 13-Mar-2020

    Summary

    Official Symbol
    ITGA3provided by HGNC
    Official Full Name
    integrin subunit alpha 3provided by HGNC
    Primary source
    HGNC:HGNC:6139
    See related
    Ensembl:ENSG00000005884 MIM:605025
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VL3A; CD49C; FRP-2; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3
    Summary
    The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]
    Expression
    Broad expression in lung (RPKM 53.0), thyroid (RPKM 21.5) and 19 other tissues See more
    Orthologs

    Genomic context

    See ITGA3 in Genome Data Viewer
    Location:
    17q21.33
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (50056065..50090481)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48133340..48167849)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene distal-less homeobox 3 Neighboring gene p53 inducible cancer associated RNA transcript 1 Neighboring gene pyruvate dehydrogenase kinase 2 Neighboring gene sterile alpha motif domain containing 14 Neighboring gene protein phosphatase 1 regulatory subunit 9B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed
    Tat tat Activation of primary T cells by HIV-1 Tat involves integrin receptors and monoclonal antibodies to integrin alpha 3 inhibit Tat-induced upregulation of CD25 PubMed
    retropepsin gag-pol Beta4 integrin and alpha3 integrin are cleaved by the HIV-1 protease in human embryonic fibroblasts PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ33213, FLJ34631, FLJ34704, FLJ37821

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    collagen binding IEA
    Inferred from Electronic Annotation
    more info
     
    fibronectin binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    laminin binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell-matrix adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    dendritic spine maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    exploration behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular matrix organization TAS
    Traceable Author Statement
    more info
     
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maternal process involved in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    memory IEA
    Inferred from Electronic Annotation
    more info
     
    mesodermal cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    nephron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epithelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal filtration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to gonadotropin IEA
    Inferred from Electronic Annotation
    more info
     
    skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface HDA PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    excitatory synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    filopodium membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion HDA PubMed 
    growth cone filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    integrin alpha3-beta1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrin alpha3-beta1 complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    invadopodium membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    integrin alpha-3
    Names
    CD49 antigen-like family member C
    alpha 3 subunit of VLA-3 receptor
    antigen CD49C
    antigen identified by monoclonal antibody J143
    galactoprotein B3
    integrin alpha 3
    integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
    testicular tissue protein Li 96
    testicular tissue protein Li 98
    very late activation protein 3 receptor, alpha-3 subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029107.2 RefSeqGene

      Range
      5135..39506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002204.4NP_002195.1  integrin alpha-3 preproprotein

      See identical proteins and their annotated locations for NP_002195.1

      Status: REVIEWED

      Source sequence(s)
      AK289961, BC150190, BU631476, DA655978
      Consensus CDS
      CCDS11558.1
      UniProtKB/Swiss-Prot
      P26006
      UniProtKB/TrEMBL
      A0A140VJM0
      Related
      ENSP00000315190.8, ENST00000320031.13
      Conserved Domains (2) summary
      smart00191
      Location:365417
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:462916
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      50056065..50090481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257308.2XP_005257365.1  integrin alpha-3 isoform X1

      Conserved Domains (2) summary
      smart00191
      Location:48108
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:327781
      Integrin_alpha2; Integrin alpha

    RNA

    1. XR_001752507.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005501.2: Suppressed sequence

      Description
      NM_005501.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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