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    SRPK SR Protein Kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36706, updated on 27-Mar-2024

    Summary

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    Official Symbol
    SRPKprovided by FlyBase
    Official Full Name
    SR Protein Kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0286813
    Locus tag
    Dmel_CG8174
    See related
    AllianceGenome:FB:FBgn0286813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    abc; BcDNA:SD03158; CG8174; Dmel\CG8174; dSRPK; dSRPK1; fs(2)abc; mat(2)syn-F; mat(2)synPL63; srpk; srpk79D; syn-PL63
    Summary
    Enables protein serine/threonine kinase activity. Involved in oocyte karyosome formation; peptidyl-serine phosphorylation; and spindle assembly involved in female meiosis. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval nervous system; extended germ band embryo; hindgut anlage; and trunk ectoderm. Orthologous to several human genes including SRPK2 (SRSF protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    51F11-51F12; 2-74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15380724..15387851)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11268229..11275356)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene double parked Neighboring gene long non-coding RNA:CR45020 Neighboring gene Stac-like Neighboring gene Metchnikowin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. abnormal chromatin (abc), a maternal-effect locus in Drosophila melanogaster. Vessey KB, et al. J Cell Sci, 1991 Feb. PMID 1905300
    2. The role of SR protein kinases in regulating lipid storage in the Drosophila fat body. Mercier J, et al. Biochem Biophys Res Commun, 2023 Mar 15. PMID 36738578
    3. Conservation and Innovation: Versatile Roles for LRP4 in Nervous System Development. DePew AT, et al. J Dev Biol, 2021 Mar 14. PMID 33799485, Free PMC Article
    4. The conserved kinase SRPK regulates karyosome formation and spindle microtubule assembly in Drosophila oocytes. Loh BJ, et al. J Cell Sci, 2012 Oct 1. PMID 22854045, Free PMC Article
    5. Distinctive features of Drosophila alternative splicing factor RS domain: implication for specific phosphorylation, shuttling, and splicing activation. Allemand E, et al. Mol Cell Biol, 2001 Feb. PMID 11158320, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of SR protein kinases in regulating lipid storage in the Drosophila fat body.
      Title: The role of SR protein kinases in regulating lipid storage in the Drosophila fat body.
    2. SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity.
      Title: SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity.
    3. A loss of SRPK severely prevents microtubule assembly for acentrosomal spindles in mature oocytes.
      Title: The conserved kinase SRPK regulates karyosome formation and spindle microtubule assembly in Drosophila oocytes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oocyte karyosome formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly involved in female meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    SR protein kinase
    Names
    CG8174-PA
    CG8174-PB
    CG8174-PC
    CG8174-PD
    CG8174-PE
    SRPK-PA
    SRPK-PB
    SRPK-PC
    SRPK-PD
    SRPK-PE
    cuaba
    female sterile abnormal chromatin
    NP_001260993.1
    NP_001369087.1
    NP_611034.2
    NP_725458.1
    NP_725459.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15380724..15387851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382195.1 → NP_001369087.1  SR protein kinase, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q7C8
      Conserved Domains (1) summary
      cl21453
      Location:600 → 763
      PKc_like; Protein Kinases, catalytic domain

    2. NM_166093.3 → NP_725458.1  SR protein kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725458.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G2J5W6, Q0E965
      Related
      FBpp0086515
      Conserved Domains (1) summary
      cd14136
      Location:600 → 763
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

    3. NM_001274064.2 → NP_001260993.1  SR protein kinase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260993.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF69, G2J5W6
      Conserved Domains (1) summary
      cd14136
      Location:600 → 763
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

    4. NM_137190.4 → NP_611034.2  SR protein kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611034.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G2J5W6, Q0E965
      Related
      FBpp0086516
      Conserved Domains (1) summary
      cd14136
      Location:600 → 763
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

    5. NM_166094.1 → NP_725459.1  SR protein kinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725459.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA05, C5WLP3
      Related
      FBpp0086517, FBtr0087385
      Conserved Domains (1) summary
      cd14136
      Location:443 → 606
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KF69 A0A0B4KF69
    A0A6M3Q7C8 A0A6M3Q7C8
    A1ZA05 A1ZA05
    Q0E965 Q0E965
    Q95SW3 Q95SW3
    Q9GSP5 Q9GSP5

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