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    IPP intracisternal A particle-promoted polypeptide [ Homo sapiens (human) ]

    Gene ID: 3652, updated on 5-Mar-2024

    Summary

    Official Symbol
    IPPprovided by HGNC
    Official Full Name
    intracisternal A particle-promoted polypeptideprovided by HGNC
    Primary source
    HGNC:HGNC:6108
    See related
    Ensembl:ENSG00000197429 MIM:147485; AllianceGenome:HGNC:6108
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KLHL27
    Summary
    The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.7), testis (RPKM 2.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IPP in Genome Data Viewer
    Location:
    1p34.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (45694324..45750653, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (45566668..45627842, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46159996..46216325, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GC-rich promoter binding protein 1 like 1 Neighboring gene ribosomal protein S15a pseudogene 10 Neighboring gene ribosomal protein L7a pseudogene 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46142481-46142981 Neighboring gene Sharpr-MPRA regulatory region 13545 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46151821-46152419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 987 Neighboring gene transmembrane protein 69 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 834 Neighboring gene uncharacterized LOC105378693 Neighboring gene ribosomal protein L6 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    actin-binding protein IPP
    Names
    kelch-like family member 27
    kelch-like protein 27

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145349.2NP_001138821.1  actin-binding protein IPP isoform 2

      See identical proteins and their annotated locations for NP_001138821.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and alternate exon in the 3' coding region compared to variant 1, that results in a frameshift. This variant encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK023880, BC032544, DA905423
      Consensus CDS
      CCDS44132.1
      UniProtKB/Swiss-Prot
      Q9Y573
      Related
      ENSP00000353024.4, ENST00000359942.8
      Conserved Domains (2) summary
      PHA03098
      Location:30540
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333376
      Kelch; KELCH repeat [structural motif]
    2. NM_005897.3NP_005888.1  actin-binding protein IPP isoform 1

      See identical proteins and their annotated locations for NP_005888.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK023880, AL604028, DA905423
      Consensus CDS
      CCDS30702.1
      UniProtKB/Swiss-Prot
      A2A6V4, D3DQ11, Q8N5C3, Q9Y573
      Related
      ENSP00000379739.3, ENST00000396478.4
      Conserved Domains (2) summary
      PHA03098
      Location:30575
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333376
      Kelch; KELCH repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      45694324..45750653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419673.1XP_047275629.1  actin-binding protein IPP isoform X2

    2. XM_006710623.5XP_006710686.1  actin-binding protein IPP isoform X3

      Conserved Domains (5) summary
      smart00612
      Location:392437
      Kelch; Kelch domain
      smart00225
      Location:38134
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00038
      Location:333377
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:28131
      BTB; BTB/POZ domain
      pfam07707
      Location:139241
      BACK; BTB And C-terminal Kelch
    3. XM_024446763.2XP_024302531.1  actin-binding protein IPP isoform X1

      UniProtKB/Swiss-Prot
      A2A6V4, D3DQ11, Q8N5C3, Q9Y573
      Conserved Domains (2) summary
      PHA03098
      Location:30575
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333376
      Kelch; KELCH repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      45566668..45627842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336421.1XP_054192396.1  actin-binding protein IPP isoform X2

    2. XM_054336424.1XP_054192399.1  actin-binding protein IPP isoform X3

    3. XM_054336420.1XP_054192395.1  actin-binding protein IPP isoform X1

      UniProtKB/Swiss-Prot
      A2A6V4, D3DQ11, Q8N5C3, Q9Y573
    4. XM_054336422.1XP_054192397.1  actin-binding protein IPP isoform X4

    5. XM_054336423.1XP_054192398.1  actin-binding protein IPP isoform X5