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    INHBB inhibin subunit beta B [ Homo sapiens (human) ]

    Gene ID: 3625, updated on 5-Mar-2024

    Summary

    Official Symbol
    INHBBprovided by HGNC
    Official Full Name
    inhibin subunit beta Bprovided by HGNC
    Primary source
    HGNC:HGNC:6067
    See related
    Ensembl:ENSG00000163083 MIM:147390; AllianceGenome:HGNC:6067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. [provided by RefSeq, Aug 2016]
    Expression
    Biased expression in fat (RPKM 16.6), testis (RPKM 13.1) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See INHBB in Genome Data Viewer
    Location:
    2q14.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (120346136..120351803)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (120780882..120786549)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (121103712..121109379)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121082735-121083235 Neighboring gene putative cuticle collagen 91 Neighboring gene CRISPRi-validated cis-regulatory element chr2.4367 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121110159-121110862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121110863-121111564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121114094-121114669 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:121130783-121131676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121133461-121134352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121152410-121153223 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121187849-121188837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121199691-121200316 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:121209011-121209167 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:121210803-121212002 Neighboring gene NANOG hESC enhancer GRCh37_chr2:121214333-121214894 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:121223679-121224221 Neighboring gene long intergenic non-protein coding RNA 1101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121256367-121256872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121261397-121261898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121269051-121269670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121269671-121270289 Neighboring gene uncharacterized LOC105373585 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:121301087-121302286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11919

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study on obesity and obesity-related traits.
    EBI GWAS Catalog
    Genetic variants associated with breast size also influence breast cancer risk.
    EBI GWAS Catalog
    Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
    EBI GWAS Catalog
    Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC157939

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables host cell surface receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adhesion of symbiont to host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to Thyroglobulin triiodothyronine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cholesterol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to leptin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to thyroid hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of follicle-stimulating hormone secretion IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in negative regulation of hepatocyte growth factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in oocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ovarian follicle development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in pituitary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of follicle-stimulating hormone secretion IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in positive regulation of ovulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to gonadotropin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insecticide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in seminiferous tubule development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    inhibin beta B chain
    Names
    Inhibin, beta-2
    activin AB beta polypeptide
    activin beta-B chain
    inhibin beta B subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002193.4NP_002184.2  inhibin beta B chain preproprotein

      See identical proteins and their annotated locations for NP_002184.2

      Status: REVIEWED

      Source sequence(s)
      AC012363, AI659282, AI671596, BC030029, BI545428, CK430845, M13437, M31682
      Consensus CDS
      CCDS2132.1
      UniProtKB/Swiss-Prot
      P09529, Q53T31, Q8N1D3
      Related
      ENSP00000295228.3, ENST00000295228.4
      Conserved Domains (2) summary
      smart00204
      Location:303406
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:57278
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      120346136..120351803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      120780882..120786549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)