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    IL15RA interleukin 15 receptor subunit alpha [ Homo sapiens (human) ]

    Gene ID: 3601, updated on 11-Apr-2024

    Summary

    Official Symbol
    IL15RAprovided by HGNC
    Official Full Name
    interleukin 15 receptor subunit alphaprovided by HGNC
    Primary source
    HGNC:HGNC:5978
    See related
    Ensembl:ENSG00000134470 MIM:601070; AllianceGenome:HGNC:5978
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD215
    Summary
    This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]
    Expression
    Ubiquitous expression in gall bladder (RPKM 5.8), lung (RPKM 5.5) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL15RA in Genome Data Viewer
    Location:
    10p15.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (5948900..5978741, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (5949580..5979435, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (5994334..6020704, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2943 Neighboring gene ribosomal protein L12 pseudogene 28 Neighboring gene ankyrin repeat domain 16 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2092 Neighboring gene F-box DNA helicase 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:5958854-5960053 Neighboring gene MPRA-validated peak859 silencer Neighboring gene uncharacterized LOC105376384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:5987078-5987636 Neighboring gene uncharacterized LOC107984200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:6006433-6006934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:6006935-6007434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2094 Neighboring gene Sharpr-MPRA regulatory region 4656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2946 Neighboring gene uncharacterized LOC124902368 Neighboring gene small nucleolar RNA SNORA14 Neighboring gene interleukin 2 receptor subunit alpha Neighboring gene uncharacterized LOC107984201

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study of bronchodilator response in asthmatics.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of IL15RA PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of interleukin 15 receptor, alpha (IL15RA) in human B cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC104179

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables interleukin-15 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-15 receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-15 receptor subunit alpha
    Names
    interleukin 15 receptor, alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243539.2NP_001230468.1  interleukin-15 receptor subunit alpha isoform 3

      See identical proteins and their annotated locations for NP_001230468.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses a downstream, in-frame start codon, compared to variant 4. The encoded isoform (3) has a shorter N-terminus compared to isoform 4.
      Source sequence(s)
      AA847313, AF035279, AL137186, BC107777
      Consensus CDS
      CCDS58069.1
      UniProtKB/Swiss-Prot
      Q13261
      Related
      ENSP00000431529.2, ENST00000525219.6
    2. NM_001256765.1NP_001243694.1  interleukin-15 receptor subunit alpha isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AA847313, AF035279, DC298692, HQ401283
      Consensus CDS
      CCDS73065.1
      UniProtKB/TrEMBL
      A0A0A0MS77, G8CVM3
      Related
      ENSP00000380421.3, ENST00000397248.6
      Conserved Domains (1) summary
      cd00033
      Location:119180
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    3. NM_001351095.2NP_001338024.1  interleukin-15 receptor subunit alpha isoform 5

      Status: REVIEWED

      Source sequence(s)
      AA847313, AK304211, AL137186, BG675498, CA308853, U31628
      Conserved Domains (1) summary
      cd00033
      Location:91152
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    4. NM_001351096.1NP_001338025.1  interleukin-15 receptor subunit alpha isoform 6

      Status: REVIEWED

      Source sequence(s)
      AF035279, AL137186, BG675498, CA308853, HQ401283
    5. NM_001351097.2NP_001338026.1  interleukin-15 receptor subunit alpha isoform 7

      Status: REVIEWED

      Source sequence(s)
      AF035279, AL137186, BC107777, CA308853
      UniProtKB/TrEMBL
      E7ETI1
      Related
      ENSP00000380420.4, ENST00000397246.7
    6. NM_002189.4NP_002180.1  interleukin-15 receptor subunit alpha isoform 1 precursor

      See identical proteins and their annotated locations for NP_002180.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame 5' coding exon, compared to variant 4. This results in a shorter isoform (1), compared to isoform 4.
      Source sequence(s)
      AA847313, U31628
      Consensus CDS
      CCDS7074.1
      UniProtKB/Swiss-Prot
      B4E2C2, Q13261, Q3B769, Q5JVA1, Q5JVA2, Q5JVA4, Q6B0J2, Q7LDR4, Q7Z609
      UniProtKB/TrEMBL
      G8CVM3
      Related
      ENSP00000369312.3, ENST00000379977.8
      Conserved Domains (1) summary
      cd00033
      Location:3394
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    7. NM_172200.3NP_751950.2  interleukin-15 receptor subunit alpha isoform 2 precursor

      See identical proteins and their annotated locations for NP_751950.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame coding exon, compared to variant 4. This results in a shorter isoform (2), compared to isoform 4.
      Source sequence(s)
      AA847313, AK304211, U31628
      Consensus CDS
      CCDS7075.2
      UniProtKB/Swiss-Prot
      Q13261
      Related
      ENSP00000435454.1, ENST00000528354.5
      Conserved Domains (1) summary
      cd00033
      Location:3394
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    RNA

    1. NR_046362.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate 5' exon structure, compared to variant 4. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 4.
      Source sequence(s)
      AA847313, AF035279, AL137186, BC065506

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      5948900..5978741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519474.3XP_011517776.1  interleukin-15 receptor subunit alpha isoform X20

    2. XM_011519471.3XP_011517773.1  interleukin-15 receptor subunit alpha isoform X15

      Conserved Domains (1) summary
      PRK14959
      Location:78188
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    3. XM_011519464.3XP_011517766.1  interleukin-15 receptor subunit alpha isoform X4

      Conserved Domains (1) summary
      cd00033
      Location:91152
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    4. XM_011519463.3XP_011517765.1  interleukin-15 receptor subunit alpha isoform X3

      Conserved Domains (1) summary
      cd00033
      Location:142203
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    5. XM_011519461.3XP_011517763.1  interleukin-15 receptor subunit alpha isoform X1

      Conserved Domains (2) summary
      cd00033
      Location:142203
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam05466
      Location:212317
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    6. XM_047425185.1XP_047281141.1  interleukin-15 receptor subunit alpha isoform X18

    7. XM_011519475.3XP_011517777.1  interleukin-15 receptor subunit alpha isoform X21

    8. XM_011519472.3XP_011517774.1  interleukin-15 receptor subunit alpha isoform X17

    9. XM_011519470.3XP_011517772.1  interleukin-15 receptor subunit alpha isoform X12

      Conserved Domains (1) summary
      cd00033
      Location:68129
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    10. XM_047425188.1XP_047281144.1  interleukin-15 receptor subunit alpha isoform X25

    11. XM_011519467.3XP_011517769.1  interleukin-15 receptor subunit alpha isoform X7

      Conserved Domains (1) summary
      cd00033
      Location:68129
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    12. XM_011519462.3XP_011517764.1  interleukin-15 receptor subunit alpha isoform X2

      Conserved Domains (2) summary
      cd00033
      Location:119180
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam05466
      Location:189294
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    13. XM_017016197.3XP_016871686.1  interleukin-15 receptor subunit alpha isoform X18

    14. XM_011519468.2XP_011517770.1  interleukin-15 receptor subunit alpha isoform X8

      Conserved Domains (2) summary
      cd00033
      Location:142203
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam05466
      Location:212317
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    15. XM_047425191.1XP_047281147.1  interleukin-15 receptor subunit alpha isoform X28

    16. XM_017016198.2XP_016871687.1  interleukin-15 receptor subunit alpha isoform X22

    17. XM_017016195.2XP_016871684.1  interleukin-15 receptor subunit alpha isoform X13

    18. XM_047425184.1XP_047281140.1  interleukin-15 receptor subunit alpha isoform X16

    19. XM_011519469.2XP_011517771.1  interleukin-15 receptor subunit alpha isoform X9

      Conserved Domains (1) summary
      cd00033
      Location:142203
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    20. XM_047425182.1XP_047281138.1  interleukin-15 receptor subunit alpha isoform X11

    21. XM_011519465.2XP_011517767.1  interleukin-15 receptor subunit alpha isoform X5

      Conserved Domains (1) summary
      cd00033
      Location:142203
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    22. XM_011519466.3XP_011517768.1  interleukin-15 receptor subunit alpha isoform X6

      Conserved Domains (2) summary
      cd00033
      Location:142203
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam05466
      Location:212317
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    23. XM_011519476.3XP_011517778.1  interleukin-15 receptor subunit alpha isoform X29

      Related
      ENSP00000380422.2, ENST00000397250.6
    24. XM_011519477.3XP_011517779.1  interleukin-15 receptor subunit alpha isoform X30

      Related
      ENSP00000369306.1, ENST00000379971.5
    25. XM_047425189.1XP_047281145.1  interleukin-15 receptor subunit alpha isoform X26

    26. XM_047425190.1XP_047281146.1  interleukin-15 receptor subunit alpha isoform X27

    27. XM_047425187.1XP_047281143.1  interleukin-15 receptor subunit alpha isoform X24

      Related
      ENSP00000435995.1, ENST00000530685.5
    28. XM_047425186.1XP_047281142.1  interleukin-15 receptor subunit alpha isoform X19

      Related
      ENSP00000380426.3, ENST00000397255.7
    29. XM_047425183.1XP_047281139.1  interleukin-15 receptor subunit alpha isoform X14

    30. XM_047425181.1XP_047281137.1  interleukin-15 receptor subunit alpha isoform X10

    31. XM_017016199.2XP_016871688.1  interleukin-15 receptor subunit alpha isoform X23

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      5949580..5979435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365790.1XP_054221765.1  interleukin-15 receptor subunit alpha isoform X25

    2. XM_054365785.1XP_054221760.1  interleukin-15 receptor subunit alpha isoform X20

    3. XM_054365779.1XP_054221754.1  interleukin-15 receptor subunit alpha isoform X15

    4. XM_054365768.1XP_054221743.1  interleukin-15 receptor subunit alpha isoform X4

    5. XM_054365767.1XP_054221742.1  interleukin-15 receptor subunit alpha isoform X3

    6. XM_054365765.1XP_054221740.1  interleukin-15 receptor subunit alpha isoform X1

    7. XM_054365782.1XP_054221757.1  interleukin-15 receptor subunit alpha isoform X18

    8. XM_054365786.1XP_054221761.1  interleukin-15 receptor subunit alpha isoform X21

    9. XM_054365781.1XP_054221756.1  interleukin-15 receptor subunit alpha isoform X17

    10. XM_054365776.1XP_054221751.1  interleukin-15 receptor subunit alpha isoform X12

    11. XM_054365771.1XP_054221746.1  interleukin-15 receptor subunit alpha isoform X7

    12. XM_054365766.1XP_054221741.1  interleukin-15 receptor subunit alpha isoform X2

    13. XM_054365783.1XP_054221758.1  interleukin-15 receptor subunit alpha isoform X18

    14. XM_054365772.1XP_054221747.1  interleukin-15 receptor subunit alpha isoform X8

    15. XM_054365793.1XP_054221768.1  interleukin-15 receptor subunit alpha isoform X28

    16. XM_054365787.1XP_054221762.1  interleukin-15 receptor subunit alpha isoform X22

    17. XM_054365777.1XP_054221752.1  interleukin-15 receptor subunit alpha isoform X13

    18. XM_054365780.1XP_054221755.1  interleukin-15 receptor subunit alpha isoform X16

    19. XM_054365773.1XP_054221748.1  interleukin-15 receptor subunit alpha isoform X9

    20. XM_054365775.1XP_054221750.1  interleukin-15 receptor subunit alpha isoform X11

    21. XM_054365769.1XP_054221744.1  interleukin-15 receptor subunit alpha isoform X5

    22. XM_054365770.1XP_054221745.1  interleukin-15 receptor subunit alpha isoform X6

    23. XM_054365794.1XP_054221769.1  interleukin-15 receptor subunit alpha isoform X29

    24. XM_054365795.1XP_054221770.1  interleukin-15 receptor subunit alpha isoform X30

    25. XM_054365791.1XP_054221766.1  interleukin-15 receptor subunit alpha isoform X26

    26. XM_054365792.1XP_054221767.1  interleukin-15 receptor subunit alpha isoform X27

    27. XM_054365789.1XP_054221764.1  interleukin-15 receptor subunit alpha isoform X24

    28. XM_054365784.1XP_054221759.1  interleukin-15 receptor subunit alpha isoform X19

    29. XM_054365778.1XP_054221753.1  interleukin-15 receptor subunit alpha isoform X14

    30. XM_054365774.1XP_054221749.1  interleukin-15 receptor subunit alpha isoform X10

    31. XM_054365788.1XP_054221763.1  interleukin-15 receptor subunit alpha isoform X23