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    Uba1 Ubiquitin activating enzyme 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35998, updated on 8-Oct-2018

    Summary

    Official Symbol
    Uba1provided by FlyBase
    Official Full Name
    Ubiquitin activating enzyme 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0023143
    Locus tag
    Dmel_CG1782
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2/31; CG1782; Dmel\CG1782; DmUba1; E1; FBtr0088499; l(2)03405; l(2)05642; l(2)s3484; Uba 1; uba-1; UBA-1; uba1

    Genomic context

    See Uba1 in Genome Data Viewer
    Location:
    46A1-46A1; 2-61 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9688289..9693328, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5575794..5580833, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Matrix metalloproteinase 2 Neighboring gene ncRNA Neighboring gene transfer RNA:initiator Methionine-CAT 2-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    • Homologs of the Uba1 gene: The Uba1 gene is conserved in human, Rhesus monkey, dog, cow, mouse, rat, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and rice.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT Atg8 activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    larval midgut cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid storage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovarian follicle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendrite IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    plasma membrane HDA PubMed 

    General protein information

    Preferred Names
    ubiquitin activating enzyme 1
    Names
    CG1782-PA
    CG1782-PC
    E1
    E1 ligase
    Uba1-PA
    Uba1-PC
    ubiquitin activating enzyme
    ubiquitin-activating enzyme (E1)

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9688289..9693328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057962.5NP_477310.2  ubiquitin activating enzyme 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477310.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0L3
      Related
      FBpp0087583, FBtr0088499
      Conserved Domains (4) summary
      cd01490
      Location:6061144
      Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      cd01491
      Location:199574
      Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      TIGR01408
      Location:1941188
      Ube1; ubiquitin-activating enzyme E1
      pfam16191
      Location:447510
      E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle
    2. NM_001273902.1NP_001260831.1  ubiquitin activating enzyme 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260831.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF46
      Related
      FBpp0308600, FBtr0339517
      Conserved Domains (4) summary
      cd01490
      Location:423961
      Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      cd01491
      Location:16391
      Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      TIGR01408
      Location:111005
      Ube1; ubiquitin-activating enzyme E1
      pfam16191
      Location:264327
      E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle
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