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    mEFTu2 mitochondrial translation elongation factor Tu 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35681, updated on 4-Apr-2024

    Summary

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    Official Symbol
    mEFTu2provided by FlyBase
    Official Full Name
    mitochondrial translation elongation factor Tu 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0033184
    Locus tag
    Dmel_CG12736
    See related
    AllianceGenome:FB:FBgn0033184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12736; Dmel\CG12736; EF-Tu2
    Summary
    Predicted to enable GTPase activity and translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Predicted to be active in mitochondrion. Is expressed in adult head; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 4. Orthologous to human TUFM (Tu translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    43D1-43D1; 2-56 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7508527..7510357, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3396032..3397862, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene disc proliferation abnormal Neighboring gene dilute class unconventional myosin Neighboring gene az2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Duplication of Drosophila melanogaster mitochondrial EF-Tu: pre-adaptation to T-arm truncation and exclusion of bulky aminoacyl residues. Sato A, et al. Biochem J, 2017 Mar 7. PMID 28130490
    2. Gene knockout by inducing P-element transposition in Drosophila. Ou HL. Genet Mol Res, 2013 Jan 4. PMID 23315879
    3. The translation factors of Drosophila melanogaster. Marygold SJ, et al. Fly (Austin), 2017 Jan 2. PMID 27494710, Free PMC Article
    4. The transcriptional response of Drosophila melanogaster to infection with the sigma virus (Rhabdoviridae). Carpenter J, et al. PLoS One, 2009 Aug 31. PMID 19718442, Free PMC Article
    5. Wolbachia and Virus Alter the Host Transcriptome at the Interface of Nucleotide Metabolism Pathways. Lindsey ARI, et al. mBio, 2021 Feb 9. PMID 33563832, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial translation elongation factor Tu 2
    Names
    CG12736-PA
    mEFTu2-PA
    translation elongation factor Tu

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7508527..7510357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136444.3 → NP_610288.1  mitochondrial translation elongation factor Tu 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610288.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3V6
      Related
      FBpp0088054
      Conserved Domains (4) summary
      cd01884
      Location:56 → 249
      EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins
      PRK00049
      Location:53 → 437
      PRK00049; elongation factor Tu; Reviewed
      cd03697
      Location:257 → 343
      EFTU_II; Domain II of elongation factor Tu
      cd03706
      Location:347 → 437
      mtEFTU_III; Domain III of mitochondrial EF-TU (mtEF-TU)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3V6 Q7K3V6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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