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    IL1RN interleukin 1 receptor antagonist [ Homo sapiens (human) ]

    Gene ID: 3557, updated on 8-Jul-2021

    Summary

    Official Symbol
    IL1RNprovided by HGNC
    Official Full Name
    interleukin 1 receptor antagonistprovided by HGNC
    Primary source
    HGNC:HGNC:6000
    See related
    Ensembl:ENSG00000136689 MIM:147679
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA
    Summary
    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Biased expression in esophagus (RPKM 367.9), bone marrow (RPKM 53.9) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See IL1RN in Genome Data Viewer
    Location:
    2q14.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (113099365..113134016)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113875548..113891591)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10370 Neighboring gene RNA, U6 small nuclear 1180, pseudogene Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene paired box 8 Neighboring gene PAX8 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    GeneReviews: Not available
    Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
    GeneReviews: Not available
    Hereditary diffuse gastric cancer Compare labs
    Microvascular complications of diabetes 4
    MedGen: C2675112 OMIM: 612628 GeneReviews: Not available
    Compare labs
    Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
    GeneReviews: Not available
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    GeneReviews: Not available
    Osteomyelitis, sterile multifocal, with periostitis and pustulosis
    MedGen: C2748507 OMIM: 612852 GeneReviews: Not available
    Compare labs

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of interleukin 1 receptor antagonist (IL1RN) in human B cells PubMed
    Tat tat HIV-1 Tat upregulates the expression of IL-1 receptor antagonist through binding to and inhibiting CD26 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC10430

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-1 receptor antagonist protein
    Names
    IL1 inhibitor
    intracellular IL-1 receptor antagonist type II
    intracellular interleukin-1 receptor antagonist (icIL-1ra)
    type II interleukin-1 receptor antagonist

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021240.1 RefSeqGene

      Range
      5001..21124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_188

    mRNA and Protein(s)

    1. NM_000577.5NP_000568.1  interleukin-1 receptor antagonist protein isoform 3

      See identical proteins and their annotated locations for NP_000568.1

      Status: REVIEWED

      Source sequence(s)
      AC024704, BC009745, M55646
      Consensus CDS
      CCDS2113.1
      UniProtKB/Swiss-Prot
      P18510
      Related
      ENSP00000329072.3, ENST00000354115.6
      Conserved Domains (1) summary
      smart00125
      Location:16156
      IL1; Interleukin-1 homologues
    2. NM_001318914.2NP_001305843.1  interleukin-1 receptor antagonist protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC024704, AF043143, BC009745, DA667440
      Consensus CDS
      CCDS2115.1
      UniProtKB/Swiss-Prot
      P18510
      UniProtKB/TrEMBL
      A0A024R528
      Conserved Domains (1) summary
      smart00125
      Location:1140
      IL1; Interleukin-1 homologues
    3. NM_001379360.1NP_001366289.1  interleukin-1 receptor antagonist protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC024704
      Conserved Domains (1) summary
      smart00125
      Location:1140
      IL1; Interleukin-1 homologues
    4. NM_173841.3NP_776213.1  interleukin-1 receptor antagonist protein isoform 2

      See identical proteins and their annotated locations for NP_776213.1

      Status: REVIEWED

      Source sequence(s)
      AC024704
      Consensus CDS
      CCDS2114.1
      UniProtKB/Swiss-Prot
      P18510
      Related
      ENSP00000259206.5, ENST00000259206.9
      Conserved Domains (1) summary
      smart00125
      Location:37177
      IL1; Interleukin-1 homologues
    5. NM_173842.3NP_776214.1  interleukin-1 receptor antagonist protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_776214.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' end compared to variant 2, resulting in an isoform (1) that has a distinct and shorter N-terminus, as compared to the longest isoform (2).
      Source sequence(s)
      AC024704, BC009745, BI766516
      Consensus CDS
      CCDS46396.1
      UniProtKB/Swiss-Prot
      P18510
      Related
      ENSP00000387173.3, ENST00000409930.4
      Conserved Domains (1) summary
      smart00125
      Location:34174
      IL1; Interleukin-1 homologues
    6. NM_173843.3NP_776215.1  interleukin-1 receptor antagonist protein isoform 4

      See identical proteins and their annotated locations for NP_776215.1

      Status: REVIEWED

      Source sequence(s)
      AC024704, AF043143, BC009745
      Consensus CDS
      CCDS2115.1
      UniProtKB/Swiss-Prot
      P18510
      UniProtKB/TrEMBL
      A0A024R528
      Related
      ENSP00000354816.3, ENST00000361779.7
      Conserved Domains (1) summary
      smart00125
      Location:1140
      IL1; Interleukin-1 homologues

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      113099365..113134016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511121.1XP_011509423.1  interleukin-1 receptor antagonist protein isoform X1

      See identical proteins and their annotated locations for XP_011509423.1

      UniProtKB/Swiss-Prot
      P18510
      UniProtKB/TrEMBL
      A0A024R528
      Related
      ENSP00000387210.1, ENST00000409052.5
      Conserved Domains (1) summary
      smart00125
      Location:1140
      IL1; Interleukin-1 homologues
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