U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    VCY1B variable charge Y-linked 1B [ Homo sapiens (human) ]

    Gene ID: 353513, updated on 17-Jun-2024

    Summary

    Official Symbol
    VCY1Bprovided by HGNC
    Official Full Name
    variable charge Y-linked 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:31751
    See related
    Ensembl:ENSG00000129862 MIM:400050; AllianceGenome:HGNC:31751
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BPY1B
    Summary
    The protein encoded by this gene is a member of a family of human VCX/Y genes. This gene family has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. Members of the VCX/Y family share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. VCX/Y genes encode small and highly charged proteins of unknown function. This gene encodes a small, positively charged protein. The presence of a putative bipartite nuclear localization signal suggests that this gene encodes a nuclear protein. The genome has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 20.7) See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See VCY1B in Genome Data Viewer
    Location:
    Yq11.221
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (14056227..14056958)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (14962884..14963615)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (16168107..16168838)

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene anosmin 2, pseudogene Neighboring gene variable charge Y-linked Neighboring gene patatin-like phospholipase domain containing 4 pseudogene 1 Neighboring gene patatin like phospholipase domain containing 4 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    testis-specific basic protein Y 1
    Names
    basic charge, Y-linked 1
    basic protein on Y chromosome, 1
    testis-specific basic protein on Y, 1
    variably charged protein Y

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181880.2NP_870996.1  testis-specific basic protein Y 1

      See identical proteins and their annotated locations for NP_870996.1

      Status: REVIEWED

      Source sequence(s)
      AC018677, BC056508
      Consensus CDS
      CCDS56618.1
      UniProtKB/Swiss-Prot
      O14598
      UniProtKB/TrEMBL
      Q4KN35
      Related
      ENSP00000250823.4, ENST00000250823.5
      Conserved Domains (1) summary
      pfam15231
      Location:1116
      VCX_VCY; Variable charge X/Y family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      14056227..14056958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      14962884..14963615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)