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    SLCO4C1 solute carrier organic anion transporter family member 4C1 [ Homo sapiens (human) ]

    Gene ID: 353189, updated on 27-Nov-2024

    Summary

    Official Symbol
    SLCO4C1provided by HGNC
    Official Full Name
    solute carrier organic anion transporter family member 4C1provided by HGNC
    Primary source
    HGNC:HGNC:23612
    See related
    Ensembl:ENSG00000173930 MIM:609013; AllianceGenome:HGNC:23612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OATPX; OATP-H; OATP-M1; OATP4C1; PRO2176; SLC21A20
    Summary
    SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in kidney (RPKM 21.4), lung (RPKM 4.2) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SLCO4C1 in Genome Data Viewer
    Location:
    5q21.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (102233986..102296284, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (102742066..102804356, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (101569690..101631988, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379102 Neighboring gene olfactory receptor family 7 subfamily H member 2 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:101467333-101467904 Neighboring gene RNA, 5S ribosomal pseudogene 188 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:101517472-101518671 Neighboring gene MPRA-validated peak5379 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22853 Neighboring gene RN7SK pseudogene 68 Neighboring gene solute carrier organic anion transporter family member 6A1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:101834092-101834592

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium-independent organic anion transport TAS
    Traceable Author Statement
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in azurophil granule membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier organic anion transporter family member 4C1
    Names
    organic anion transporter M1
    organic anion transporting polypeptide 4C1
    solute carrier family 21 member 20

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_180991.5NP_851322.3  solute carrier organic anion transporter family member 4C1

      See identical proteins and their annotated locations for NP_851322.3

      Status: VALIDATED

      Source sequence(s)
      AK128854, AY273896, BX647349, BX647577
      Consensus CDS
      CCDS34205.1
      UniProtKB/Swiss-Prot
      Q6ZQN7, Q86UG5
      Related
      ENSP00000309741.6, ENST00000310954.7
      Conserved Domains (1) summary
      cd17463
      Location:104604
      MFS_SLCO4C_OATP4C; Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      102233986..102296284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543370.3XP_011541672.1  solute carrier organic anion transporter family member 4C1 isoform X1

      Conserved Domains (3) summary
      cd06174
      Location:158397
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:411461
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:156576
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    2. XM_047417146.1XP_047273102.1  solute carrier organic anion transporter family member 4C1 isoform X2

    3. XM_011543372.2XP_011541674.1  solute carrier organic anion transporter family member 4C1 isoform X2

      Conserved Domains (2) summary
      cd01330
      Location:361411
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:1526
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      102742066..102804356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352514.1XP_054208489.1  solute carrier organic anion transporter family member 4C1 isoform X1

    2. XM_054352516.1XP_054208491.1  solute carrier organic anion transporter family member 4C1 isoform X2

    3. XM_054352517.1XP_054208492.1  solute carrier organic anion transporter family member 4C1 isoform X2

    4. XM_054352515.1XP_054208490.1  solute carrier organic anion transporter family member 4C1 isoform X2