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    RBPJ recombination signal binding protein for immunoglobulin kappa J region [ Homo sapiens (human) ]

    Gene ID: 3516, updated on 2-Aug-2021

    Summary

    Official Symbol
    RBPJprovided by HGNC
    Official Full Name
    recombination signal binding protein for immunoglobulin kappa J regionprovided by HGNC
    Primary source
    HGNC:HGNC:5724
    See related
    Ensembl:ENSG00000168214 MIM:147183
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SUH; csl; AOS3; CBF1; KBF2; CBF-1; RBP-J; RBPJK; IGKJRB; RBP-JK; RBPSUH; IGKJRB1; RBP-J kappa
    Summary
    The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]
    Expression
    Ubiquitous expression in placenta (RPKM 17.3), endometrium (RPKM 16.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RBPJ in Genome Data Viewer
    Location:
    4p15.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (26163458..26435131)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (26165080..26436753)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2357 Neighboring gene zinc finger protein 248 pseudogene Neighboring gene uncharacterized LOC105374541 Neighboring gene uncharacterized LOC105374545 Neighboring gene uncharacterized LOC105374542 Neighboring gene Sharpr-MPRA regulatory region 12863 Neighboring gene cholecystokinin A receptor Neighboring gene TBC1 domain family member 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Adams-Oliver syndrome 3
    MedGen: C3553748 OMIM: 614814 GeneReviews: Adams-Oliver Syndrome
    Compare labs
    Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
    GeneReviews: Not available
    Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC61669

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein N-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Notch signaling involved in heart development IC
    Inferred by Curator
    more info
    PubMed 
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in aortic valve development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in arterial endothelial cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in atrioventricular canal development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in auditory receptor cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood vessel endothelial cell fate specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in blood vessel lumenization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in blood vessel remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac left ventricle morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in club cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dorsal aorta morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endocardium morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epidermal cell fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epithelial to mesenchymal transition involved in endocardial cushion formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hair follicle maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in humoral immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in labyrinthine layer blood vessel development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in myeloid dendritic cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of ossification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in outflow tract morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pituitary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of ERBB signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardiac muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell proliferation involved in heart morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of ephrin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription of Notch receptor target IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pulmonary valve development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of timing of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sebaceous gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in secondary heart field specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in somatic stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular trabecula myocardium morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of MAML1-RBP-Jkappa- ICN1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MAML1-RBP-Jkappa- ICN1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    recombining binding protein suppressor of hairless
    Names
    H-2K binding factor-2
    immunoglobulin kappa J region recombination signal binding protein 1
    renal carcinoma antigen NY-REN-30
    suppressor of hairless homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030343.1 RefSeqGene

      Range
      5001..120422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001363577.2NP_001350506.1  recombining binding protein suppressor of hairless isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC093637, AC097109
      Consensus CDS
      CCDS87214.1
      Related
      ENSP00000505636.1, ENST00000681484.1
      Conserved Domains (3) summary
      cd01176
      Location:315411
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:171293
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:13138
      LAG1-DNAbind; LAG1, DNA binding
    2. NM_001374400.1NP_001361329.1  recombining binding protein suppressor of hairless isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC093637, AC097109
      Related
      ENSP00000423644.2, ENST00000512671.6
      Conserved Domains (3) summary
      cd01176
      Location:350446
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:206328
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:48173
      LAG1-DNAbind; LAG1, DNA binding
    3. NM_001374401.1NP_001361330.1  recombining binding protein suppressor of hairless isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC093637, AC097109, AC097714
      Conserved Domains (3) summary
      cd01176
      Location:336432
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:192314
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:34159
      LAG1-DNAbind; LAG1, DNA binding
    4. NM_001374402.1NP_001361331.1  recombining binding protein suppressor of hairless isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC093637, AC097109
      Conserved Domains (3) summary
      cd01176
      Location:336432
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:192314
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:34159
      LAG1-DNAbind; LAG1, DNA binding
    5. NM_001374403.1NP_001361332.1  recombining binding protein suppressor of hairless isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC093637, AC097109
      Related
      ENSP00000505493.1, ENST00000680928.1
      Conserved Domains (3) summary
      cd01176
      Location:336432
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:192314
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:34159
      LAG1-DNAbind; LAG1, DNA binding
    6. NM_001379406.1NP_001366335.1  recombining binding protein suppressor of hairless isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC093637, AC097109
      Conserved Domains (3) summary
      cd01176
      Location:336432
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:192314
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:34159
      LAG1-DNAbind; LAG1, DNA binding
    7. NM_001379407.1NP_001366336.1  recombining binding protein suppressor of hairless isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC093637, AC097109
      Conserved Domains (3) summary
      cd01176
      Location:336432
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:192314
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:34159
      LAG1-DNAbind; LAG1, DNA binding
    8. NM_001379408.1NP_001366337.1  recombining binding protein suppressor of hairless isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC093637, AC097109
    9. NM_001379409.1NP_001366338.1  recombining binding protein suppressor of hairless isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC093637, AC097109
      Conserved Domains (3) summary
      cd01176
      Location:294379
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:191294
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:33158
      LAG1-DNAbind; LAG1, DNA binding
    10. NM_005349.4NP_005340.2  recombining binding protein suppressor of hairless isoform 1

      See identical proteins and their annotated locations for NP_005340.2

      Status: REVIEWED

      Source sequence(s)
      AC093637, AC097109
      Consensus CDS
      CCDS3437.1
      UniProtKB/Swiss-Prot
      Q06330
      Related
      ENSP00000345206.1, ENST00000342295.6
      Conserved Domains (3) summary
      cd01176
      Location:350446
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:206328
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:48173
      LAG1-DNAbind; LAG1, DNA binding
    11. NM_015874.6NP_056958.3  recombining binding protein suppressor of hairless isoform 2

      See identical proteins and their annotated locations for NP_056958.3

      Status: REVIEWED

      Source sequence(s)
      AC093637, AC097109
      Consensus CDS
      CCDS43219.1
      UniProtKB/Swiss-Prot
      Q06330
      Related
      ENSP00000347659.4, ENST00000355476.8
      Conserved Domains (3) summary
      cd01176
      Location:337433
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:193315
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:35160
      LAG1-DNAbind; LAG1, DNA binding
    12. NM_203283.5NP_976028.2  recombining binding protein suppressor of hairless isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC093637, AC097109
      Consensus CDS
      CCDS3436.1
      Related
      ENSP00000305815.6, ENST00000345843.8
      Conserved Domains (3) summary
      cd01176
      Location:315411
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:171293
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:13138
      LAG1-DNAbind; LAG1, DNA binding
    13. NM_203284.3NP_976029.1  recombining binding protein suppressor of hairless isoform 4

      See identical proteins and their annotated locations for NP_976029.1

      Status: REVIEWED

      Source sequence(s)
      AC093637, AC097109
      Consensus CDS
      CCDS33969.1
      UniProtKB/Swiss-Prot
      Q06330
      Related
      ENSP00000339699.5, ENST00000348160.9
      Conserved Domains (3) summary
      cd01176
      Location:336432
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:192314
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:34159
      LAG1-DNAbind; LAG1, DNA binding

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

      Range
      26163458..26435131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008170.2XP_016863659.1  recombining binding protein suppressor of hairless isoform X1

      Conserved Domains (3) summary
      cd01176
      Location:356452
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:185334
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:54183
      LAG1-DNAbind; LAG1, DNA binding
    2. XM_017008174.2XP_016863663.1  recombining binding protein suppressor of hairless isoform X3

      UniProtKB/Swiss-Prot
      Q06330
      Related
      ENSP00000504964.1, ENST00000681093.1
      Conserved Domains (3) summary
      cd01176
      Location:336432
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:192314
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:34159
      LAG1-DNAbind; LAG1, DNA binding
    3. XM_011513840.3XP_011512142.1  recombining binding protein suppressor of hairless isoform X3

      See identical proteins and their annotated locations for XP_011512142.1

      UniProtKB/Swiss-Prot
      Q06330
      Related
      ENSP00000426872.2, ENST00000505958.6
      Conserved Domains (3) summary
      cd01176
      Location:336432
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:192314
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:34159
      LAG1-DNAbind; LAG1, DNA binding
    4. XM_017008171.2XP_016863660.1  recombining binding protein suppressor of hairless isoform X2

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