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    cact cactus [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34969, updated on 4-Nov-2018

    Summary

    Official Symbol
    cactprovided by FlyBase
    Official Full Name
    cactusprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000250
    Locus tag
    Dmel_CG5848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    5848; BG:DS02740.15; cac; Cact; CACT; Cactus; CG5848; dip6; Dmel\CG5848; fs(2)ltoRN48; Ikappa; n(2)k17003; NFkappabeta1A

    Genomic context

    See cact in Genome Data Viewer
    Location:
    35F1-35F1; 2-52 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16313036..16326207, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16313036..16326207, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Syntaxin 5 Neighboring gene cornichon Neighboring gene fizzy Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    • Homologs of the cact gene: The cact gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, and frog.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    Toll signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    antifungal humoral response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    antimicrobial humoral response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    dorsal appendage formation HMP PubMed 
    dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral axis specification TAS
    Traceable Author Statement
    more info
    PubMed 
    hemopoiesis TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oogenesis HMP PubMed 
    positive regulation of antifungal peptide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to fungus TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cactus
    Names
    CG5848-PA
    CG5848-PB
    CG5848-PC
    CG5848-PD
    CG5848-PE
    NF-kappa-B inhibitor cactus
    cact-PA
    cact-PB
    cact-PC
    cact-PD
    cact-PE
    female-sterile-(2)-ltoRN48

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16313036..16326207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057594.4NP_476942.1  cactus, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476942.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03017
      UniProtKB/TrEMBL
      M9PD95
      Related
      FBpp0080403, FBtr0080845
      Conserved Domains (5) summary
      cd00204
      Location:260416
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:270391
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:230286
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:381438
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:229263
      ANK; ANK repeat [structural motif]
    2. NM_001273567.1NP_001260496.1  cactus, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260496.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03017
      UniProtKB/TrEMBL
      M9PD95
      Related
      FBpp0308004, FBtr0337081
      Conserved Domains (5) summary
      cd00204
      Location:260416
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:270391
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:230286
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:381438
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:229263
      ANK; ANK repeat [structural motif]
    3. NM_165152.2NP_723960.1  cactus, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723960.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03017
      UniProtKB/TrEMBL
      M9PD95
      Related
      FBpp0080402, FBtr0080844
      Conserved Domains (5) summary
      cd00204
      Location:260416
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:270391
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:230286
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:381438
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:229263
      ANK; ANK repeat [structural motif]
    4. NM_205999.2NP_995721.1  cactus, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995721.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03017
      UniProtKB/TrEMBL
      M9PD95
      Related
      FBpp0089296, FBtr0080847
      Conserved Domains (5) summary
      cd00204
      Location:260416
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:270391
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:230286
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:381438
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:229263
      ANK; ANK repeat [structural motif]
    5. NM_057595.4NP_476943.1  cactus, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476943.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03017
      Related
      FBpp0080404, FBtr0080846
      Conserved Domains (5) summary
      cd00204
      Location:260416
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:270391
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:230286
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:381438
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:229263
      ANK; ANK repeat [structural motif]
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