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    RTN4RL2 reticulon 4 receptor like 2 [ Homo sapiens (human) ]

    Gene ID: 349667, updated on 11-Apr-2024

    Summary

    Official Symbol
    RTN4RL2provided by HGNC
    Official Full Name
    reticulon 4 receptor like 2provided by HGNC
    Primary source
    HGNC:HGNC:23053
    See related
    Ensembl:ENSG00000186907 MIM:610462; AllianceGenome:HGNC:23053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NgR2; NGRH1
    Summary
    Enables signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway; corpus callosum development; and negative regulation of neuron projection development. Located in cell surface. Is anchored component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 9.9), thyroid (RPKM 5.5) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RTN4RL2 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (57460528..57477534)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (57410743..57427752)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57228001..57245007)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 341 Neighboring gene RN7SK pseudogene 259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3348 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57229713-57230251 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57231341-57231845 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57231895-57232490 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:57235875-57236324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57241779-57242279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57243453-57244281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3350 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:57256964-57257464 Neighboring gene solute carrier family 43 member 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:57260708-57261907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57267535-57268310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57268311-57269084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4719 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:57293175-57293772 Neighboring gene RNA, 7SL, cytoplasmic 605, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon regeneration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    reticulon-4 receptor-like 2
    Names
    Nogo-66 receptor homolog 1
    nogo receptor-like 3
    nogo-66 receptor-related protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178570.3NP_848665.1  reticulon-4 receptor-like 2 precursor

      See identical proteins and their annotated locations for NP_848665.1

      Status: VALIDATED

      Source sequence(s)
      AF532858, AP002893, BC113673, BE410139, BU845536, HY323308
      Consensus CDS
      CCDS7957.1
      UniProtKB/Swiss-Prot
      Q0GGW3, Q17RL9, Q6X813, Q86UN3
      UniProtKB/TrEMBL
      B7ZLI0
      Related
      ENSP00000335397.3, ENST00000335099.8
      Conserved Domains (4) summary
      cd00116
      Location:103261
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6283
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:156215
      LRR_8; Leucine rich repeat
      cl15307
      Location:261311
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      57460528..57477534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      57410743..57427752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)