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    ACSM2B acyl-CoA synthetase medium chain family member 2B [ Homo sapiens (human) ]

    Gene ID: 348158, updated on 17-Jun-2024

    Summary

    Official Symbol
    ACSM2Bprovided by HGNC
    Official Full Name
    acyl-CoA synthetase medium chain family member 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:30931
    See related
    Ensembl:ENSG00000066813 MIM:614359; AllianceGenome:HGNC:30931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HXMA; ACSM2; HYST1046
    Summary
    Enables benzoate-CoA ligase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward kidney (RPKM 155.6) See more
    Orthologs
    NEW
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    Genomic context

    See ACSM2B in Genome Data Viewer
    Location:
    16p12.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (20536226..20576367, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (20467090..20507346, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (20547548..20587689, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371119 Neighboring gene acyl-CoA synthetase medium chain family member 2A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:20503203-20503703 Neighboring gene uncharacterized LOC105371120 Neighboring gene acyl-coenzyme A synthetase ACSM5, mitochondrial-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables CoA-ligase activity TAS
    Traceable Author Statement
    more info
     
    enables benzoate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables decanoate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fatty-acyl-CoA synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables medium-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    acyl-coenzyme A synthetase ACSM2B, mitochondrial
    Names
    acyl-CoA synthetase medium-chain family member 2
    benzoate--CoA ligase
    butyrate--CoA ligase 2B
    butyryl-coenzyme A synthetase 2B
    middle-chain acyl-CoA synthetase 2B
    xenobiotic/medium-chain fatty acid-CoA ligase HXM-A
    xenobiotic/medium-chain fatty acid:CoA ligase
    NP_001098539.1
    NP_001397831.1
    NP_872423.3
    XP_016878694.1
    XP_047290012.1
    XP_054236212.1
    XP_054236213.1
    XP_054236214.1
    XP_054236215.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105069.2NP_001098539.1  acyl-coenzyme A synthetase ACSM2B, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001098539.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC141053, AC141273
      Consensus CDS
      CCDS10586.1
      UniProtKB/Swiss-Prot
      Q68CK6, Q86YT1
      UniProtKB/TrEMBL
      A8K051
      Related
      ENSP00000327453.6, ENST00000329697.10
      Conserved Domains (1) summary
      cl17068
      Location:40568
      AFD_class_I; Adenylate forming domain, Class I superfamily
    2. NM_001410902.1NP_001397831.1  acyl-coenzyme A synthetase ACSM2B, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC141053, AC141273
      Consensus CDS
      CCDS92120.1
      UniProtKB/TrEMBL
      B7Z530, H3BTX9
      Related
      ENSP00000457377.1, ENST00000565322.5
    3. NM_182617.4NP_872423.3  acyl-coenzyme A synthetase ACSM2B, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_872423.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC141053, AC141273
      Consensus CDS
      CCDS10586.1
      UniProtKB/Swiss-Prot
      Q68CK6, Q86YT1
      UniProtKB/TrEMBL
      A8K051
      Related
      ENSP00000456378.1, ENST00000567001.5
      Conserved Domains (1) summary
      cl17068
      Location:40568
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      20536226..20576367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434056.1XP_047290012.1  acyl-coenzyme A synthetase ACSM2B, mitochondrial isoform X2

    2. XM_017023205.3XP_016878694.1  acyl-coenzyme A synthetase ACSM2B, mitochondrial isoform X1

    RNA

    1. XR_001751899.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      20467090..20507346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380237.1XP_054236212.1  acyl-coenzyme A synthetase ACSM2B, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A8K051
    2. XM_054380240.1XP_054236215.1  acyl-coenzyme A synthetase ACSM2B, mitochondrial isoform X4

    3. XM_054380238.1XP_054236213.1  acyl-coenzyme A synthetase ACSM2B, mitochondrial isoform X1

    4. XM_054380239.1XP_054236214.1  acyl-coenzyme A synthetase ACSM2B, mitochondrial isoform X1

    RNA

    1. XR_008489084.1 RNA Sequence