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    RAB41 RAB41, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 347517, updated on 27-Nov-2024

    Summary

    Official Symbol
    RAB41provided by HGNC
    Official Full Name
    RAB41, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:18293
    See related
    Ensembl:ENSG00000147127 AllianceGenome:HGNC:18293
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. These proteins function as regulators of membrane trafficking. They cycle between inactive GDP-bound and activated GTP-bound states, which is controlled by GTP hydrolysis-activating proteins (GAPs). This family member can be activated by the GAP protein RN-Tre, and it is localized to the Golgi complex. [provided by RefSeq, May 2010]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See RAB41 in Genome Data Viewer
    Location:
    Xq13.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (70282172..70285002)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (68715490..68718320)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (69502022..69504852)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5483 Neighboring gene pyrimidinergic receptor P2Y4 Neighboring gene arrestin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20889 Neighboring gene PDZ domain containing 11 Neighboring gene kinesin family member 4A Neighboring gene TRAPPC2L pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-41
    Names
    RAB41, member RAS homolog family

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021267.1 RefSeqGene

      Range
      5001..7831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032726.3NP_001027898.2  ras-related protein Rab-41 isoform 1

      See identical proteins and their annotated locations for NP_001027898.2

      Status: REVIEWED

      Source sequence(s)
      AI126463, AL357752, BC117239
      Consensus CDS
      CCDS35322.2
      UniProtKB/Swiss-Prot
      Q5JT25
      Related
      ENSP00000276066.4, ENST00000276066.4
      Conserved Domains (1) summary
      cd01861
      Location:33191
      Rab6; Rab GTPase family 6 (Rab6)
    2. NM_001363807.1NP_001350736.1  ras-related protein Rab-41 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL357752
      Consensus CDS
      CCDS87756.1
      UniProtKB/Swiss-Prot
      Q17RQ0, Q5JT25
      Related
      ENSP00000363597.2, ENST00000374473.6
      Conserved Domains (1) summary
      cd01861
      Location:33192
      Rab6; Rab GTPase family 6 (Rab6)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      70282172..70285002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530948.4XP_011529250.1  ras-related protein Rab-41 isoform X1

      Conserved Domains (2) summary
      smart00175
      Location:33195
      RAB; Rab subfamily of small GTPases
      cd01861
      Location:33192
      Rab6; Rab GTPase family 6 (Rab6)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      68715490..68718320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327002.1XP_054182977.1  ras-related protein Rab-41 isoform X1