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    PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 [ Homo sapiens (human) ]

    Gene ID: 345557, updated on 5-Mar-2024

    Summary

    Official Symbol
    PLCXD3provided by HGNC
    Official Full Name
    phosphatidylinositol specific phospholipase C X domain containing 3provided by HGNC
    Primary source
    HGNC:HGNC:31822
    See related
    Ensembl:ENSG00000182836 MIM:617016; AllianceGenome:HGNC:31822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in lipid catabolic process and signal transduction. Predicted to be located in cytoplasm. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart (RPKM 12.4), ovary (RPKM 9.3) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    5p13.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (41306952..41510601, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (41563425..41766981, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (41307054..41510703, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374739 Neighboring gene NANOG hESC enhancer GRCh37_chr5:41230420-41230921 Neighboring gene NANOG hESC enhancer GRCh37_chr5:41252597-41253129 Neighboring gene complement C6 Neighboring gene uncharacterized LOC124900969 Neighboring gene uncharacterized LOC102723740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15985 Neighboring gene uncharacterized LOC105374740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:41510229-41511057 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:41587798-41587931 Neighboring gene t-complex 1 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:41717601-41717785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22505 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:41775532-41776072 Neighboring gene Sharpr-MPRA regulatory region 14195 Neighboring gene 3-oxoacid CoA-transferase 1 Neighboring gene Sharpr-MPRA regulatory region 14906 Neighboring gene NANOG hESC enhancer GRCh37_chr5:41822074-41822575 Neighboring gene uncharacterized LOC102723752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22506 Neighboring gene OXCT1 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphoric diester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    PI-PLC X domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005473.3NP_001005473.1  PI-PLC X domain-containing protein 3

      See identical proteins and their annotated locations for NP_001005473.1

      Status: VALIDATED

      Source sequence(s)
      AC008830, AK127142, BX648329
      Consensus CDS
      CCDS34150.1
      UniProtKB/Swiss-Prot
      A6NL04, Q63HM9
      UniProtKB/TrEMBL
      B3KXD1
      Related
      ENSP00000367032.3, ENST00000377801.8
      Conserved Domains (1) summary
      cd08616
      Location:19311
      PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      41306952..41510601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009438.3XP_016864927.1  PI-PLC X domain-containing protein 3 isoform X1

      Conserved Domains (1) summary
      cd08616
      Location:1239
      PI-PLCXD1c; Catalytic domain of phosphatidylinositol-specific phospholipase C, X domain containing 1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      41563425..41766981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352510.1XP_054208485.1  PI-PLC X domain-containing protein 3 isoform X1