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    Ge-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34541, updated on 27-Mar-2024

    Summary

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    Official Symbol
    Ge-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0283682
    Locus tag
    Dmel_CG6181
    See related
    AllianceGenome:FB:FBgn0283682
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6181; dGe-1; Dmel\CG6181; EDC4; GE-1; ref(2)M; Ref(2)Me
    Summary
    Involved in several processes, including P-body assembly; pole plasm oskar mRNA localization; and posttranscriptional regulation of gene expression. Located in P-body and pole plasm. Is expressed in several structures, including egg chamber; embryonic brain; embryonic/larval nervous system; extended germ band embryo; and procephalic neuroblast. Orthologous to human EDC4 (enhancer of mRNA decapping 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Ge-1 in Genome Data Viewer
    Location:
    32D3-32D3; 2-44 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11095150..11100888, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11095150..11100888, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene WD repeat domain 59 Neighboring gene RALBP1 associated Eps domain containing Neighboring gene lethal (2) giant discs 1 Neighboring gene alpha-L-iduronidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Why do Individuals Differ in Viral Susceptibility? A Story Told by Model Organisms. van Sluijs L, et al. Viruses, 2017 Sep 30. PMID 28973976, Free PMC Article
    2. The C-terminal region of Ge-1 presents conserved structural features required for P-body localization. Jinek M, et al. RNA, 2008 Oct. PMID 18755833, Free PMC Article
    3. HPat a decapping activator interacting with the miRNA effector complex. Barišić-Jäger E, et al. PLoS One, 2013. PMID 23977167, Free PMC Article
    4. [Drosophila genes which intervene in multiplication of sigma virus (author's transl)]. Gay P. Mol Gen Genet, 1978 Feb 27. PMID 416336
    5. HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs. Hanet A, et al. Life Sci Alliance, 2019 Oct. PMID 31570513, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we identified a deletion in the protein-coding region of a gene called Ge-1 in flies that are highly resistant to a naturally occurring virus called sigma virus
      Title: A Polymorphism in the Processing Body Component Ge-1 Controls Resistance to a Naturally Occurring Rhabdovirus in Drosophila.
    2. Findings suggest an important role of dGe-1 in optimization of the osk mRNA localization process required for patterning the Drosophila embryo.
      Title: Drosophila Ge-1 promotes P body formation and oskar mRNA localization.
    3. The three-dimensional crystal structure of the most conserved region of the Drosophila melanogaster Ge-1 C-terminal domain was determined.
      Title: The C-terminal region of Ge-1 presents conserved structural features required for P-body localization.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P-body assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in miRNA-mediated post-transcriptional gene silencing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pole plasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ge-1
    Names
    CG6181-PA
    CG6181-PB
    Ge-1 ortholog
    Ge-1-PA
    Ge-1-PB
    refractory to sigma M

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11095150..11100888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164957.2 → NP_723654.1  Ge-1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723654.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MZ42, Q9VKK1
      Related
      FBpp0079819
      Conserved Domains (3) summary
      pfam16529
      Location:119 → 452
      Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
      sd00039
      Location:144 → 185
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:314 → 444
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_135642.3 → NP_609486.2  Ge-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609486.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MZ42, Q9VKK1
      Related
      FBpp0079818
      Conserved Domains (3) summary
      pfam16529
      Location:119 → 452
      Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
      sd00039
      Location:144 → 185
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:314 → 444
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKK1.2 Q9VKK1

    Gene LinkOut

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