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    EMC3 ER membrane protein complex subunit 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34479, updated on 11-Apr-2024

    Summary

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    Official Symbol
    EMC3provided by FlyBase
    Official Full Name
    ER membrane protein complex subunit 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0032292
    Locus tag
    Dmel_CG6750
    See related
    AllianceGenome:FB:FBgn0032292
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6750; Dmel\CG6750; dPob; dPOB; emc3
    Summary
    Involved in rhabdomere development and rhodopsin biosynthetic process. Located in endoplasmic reticulum. Part of EMC complex. Is expressed in adult head and adult heart. Orthologous to human EMC3 (ER membrane protein complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    32A5-32A5; 2-43 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10731400..10732423, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10731400..10732423, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dpy-30-like 1 Neighboring gene Nucleoporin 107kD Neighboring gene Vacuolar H[+] ATPase 16kD subunit 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dumpy-30 family members as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. Vardanyan A, et al. BMC Dev Biol, 2008 Jun 27. PMID 18588663, Free PMC Article
    2. ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. Xiong L, et al. Cell Death Differ, 2020 Feb. PMID 31263175, Free PMC Article
    3. dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors. Satoh T, et al. Elife, 2015 Feb 26. PMID 25715730, Free PMC Article
    4. Membrane protein trafficking in Drosophila photoreceptor cells. Schopf K, et al. Eur J Cell Biol, 2017 Aug. PMID 27964885
    5. Application of Fluorescent Proteins for Functional Dissection of the Drosophila Visual System. Smylla TK, et al. Int J Mol Sci, 2021 Aug 19. PMID 34445636, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhodopsin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tail-anchored membrane protein insertion into ER membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing HMP PubMed 
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ER membrane protein complex subunit 3
    Names
    CG6750-PA
    EMC3-PA
    ER membrane protein complex 3
    endoplasmic reticulum membrane protein complex 3
    subunit 3 of EMC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10731400..10732423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135600.3 → NP_609444.1  ER membrane protein complex subunit 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609444.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKR0
      Related
      FBpp0079711
      Conserved Domains (1) summary
      pfam01956
      Location:3 → 185
      DUF106; Integral membrane protein DUF106
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKR0 Q9VKR0

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