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    SH3RF3 SH3 domain containing ring finger 3 [ Homo sapiens (human) ]

    Gene ID: 344558, updated on 7-Apr-2024

    Summary

    Official Symbol
    SH3RF3provided by HGNC
    Official Full Name
    SH3 domain containing ring finger 3provided by HGNC
    Primary source
    HGNC:HGNC:24699
    See related
    Ensembl:ENSG00000172985 MIM:618933; AllianceGenome:HGNC:24699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    POSH2; SH3MD4
    Summary
    Enables ubiquitin protein ligase activity. Involved in positive regulation of JNK cascade and protein autoubiquitination. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 1.9), gall bladder (RPKM 1.8) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    2q13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (109129205..109504634)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (109589723..109965692)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (109745661..110262211)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RAN binding protein 2 Neighboring gene coiled-coil domain containing 138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109526299-109526800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109545693-109546192 Neighboring gene ribosomal protein L39 pseudogene 16 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:109573418-109574617 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:109588237-109589436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109589833-109590332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109604149-109604650 Neighboring gene ectodysplasin A receptor Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:109636621-109637336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109663535-109664035 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:109685726-109686670 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:109705183-109705390 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:109719016-109719749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11857 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11858 Neighboring gene SH3RF3 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:109793904-109794078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16355 Neighboring gene microRNA 4265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11859 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16361 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16359 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:109876451-109876952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:109876953-109877452 Neighboring gene Sharpr-MPRA regulatory region 14332 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:109891529-109891729 Neighboring gene Sharpr-MPRA regulatory region 6940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:109933325-109934314 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:109934315-109935303 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 9 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:109964015-109964260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16362 Neighboring gene microRNA 4266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110012695-110013196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110013197-110013696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110031578-110032191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110032192-110032804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110046278-110046841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110063255-110063754 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:110065234-110065738 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110275114-110275653 Neighboring gene Sharpr-MPRA regulatory region 2497 Neighboring gene MPRA-validated peak3814 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110352345-110352845 Neighboring gene septin 10 Neighboring gene ribosomal protein L37 pseudogene 12 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:110370433-110371342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11861 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11862 Neighboring gene sosondowah ankyrin repeat domain family member C

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ00204

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein autoubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase SH3RF3
    Names
    SH3 domain-containing RING finger protein 3
    SH3 multiple domains 4
    plenty of SH3s-2
    NP_001092759.1
    XP_011509411.1
    XP_011509412.1
    XP_047300100.1
    XP_054197741.1
    XP_054197742.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099289.3NP_001092759.1  E3 ubiquitin-protein ligase SH3RF3

      See identical proteins and their annotated locations for NP_001092759.1

      Status: VALIDATED

      Source sequence(s)
      AA916456, AC133109, AK074131, DQ307286, DV080665, HY224642
      Consensus CDS
      CCDS74557.1
      UniProtKB/Swiss-Prot
      A0SDZ7, A8MPR1, Q8NDU1, Q8TEJ3
      Related
      ENSP00000309186.6, ENST00000309415.8
      Conserved Domains (5) summary
      cd11785
      Location:827881
      SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
      cd11925
      Location:467523
      SH3_SH3RF3_3; Third Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
      cd11928
      Location:197250
      SH3_SH3RF3_1; First Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
      cd11931
      Location:260314
      SH3_SH3RF3_2; Second Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
      cd00162
      Location:5698
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      109129205..109504634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511109.3XP_011509411.1  E3 ubiquitin-protein ligase SH3RF3 isoform X1

      Conserved Domains (5) summary
      cd11925
      Location:467523
      SH3_SH3RF3_3; Third Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
      cd11928
      Location:197250
      SH3_SH3RF3_1; First Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
      cd11931
      Location:260314
      SH3_SH3RF3_2; Second Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
      PLN02217
      Location:516649
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      cd16750
      Location:5398
      RING-HC_SH3RF3; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 3 (SH3RF3) and similar proteins
    2. XM_047444144.1XP_047300100.1  E3 ubiquitin-protein ligase SH3RF3 isoform X2

    3. XM_011511110.3XP_011509412.1  E3 ubiquitin-protein ligase SH3RF3 isoform X3

      Conserved Domains (3) summary
      cd11785
      Location:502556
      SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
      cd11925
      Location:142198
      SH3_SH3RF3_3; Third Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
      PLN02217
      Location:191324
      PLN02217; probable pectinesterase/pectinesterase inhibitor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      109589723..109965692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341766.1XP_054197741.1  E3 ubiquitin-protein ligase SH3RF3 isoform X2

    2. XM_054341767.1XP_054197742.1  E3 ubiquitin-protein ligase SH3RF3 isoform X3

    RNA

    1. XR_008486359.1 RNA Sequence