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    MSGN1 mesogenin 1 [ Homo sapiens (human) ]

    Gene ID: 343930, updated on 5-Mar-2024

    Summary

    Official Symbol
    MSGN1provided by HGNC
    Official Full Name
    mesogenin 1provided by HGNC
    Primary source
    HGNC:HGNC:14907
    See related
    Ensembl:ENSG00000151379 MIM:612209; AllianceGenome:HGNC:14907
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MSOG; pMsgn1
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in mesoderm formation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within segment specification and somitogenesis. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See MSGN1 in Genome Data Viewer
    Location:
    2p24.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (17816460..17817798)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (17848194..17849532)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (17997727..17999065)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene structural maintenance of chromosomes 6 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:17929152-17929835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11190 Neighboring gene uncharacterized LOC105373449 Neighboring gene GEN1 Holliday junction 5' flap endonuclease Neighboring gene Sharpr-MPRA regulatory region 14936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15356 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:18008377-18009074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:18011228-18011728 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11191 Neighboring gene uncharacterized LOC112267888 Neighboring gene zona pellucida glycoprotein AX, pseudogene Neighboring gene uncharacterized LOC124907737

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesoderm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in segment specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    mesogenin-1
    Names
    pMesogenin1
    paraxial mesoderm-specific mesogenin1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105569.3NP_001099039.1  mesogenin-1

      See identical proteins and their annotated locations for NP_001099039.1

      Status: VALIDATED

      Source sequence(s)
      AC093731
      Consensus CDS
      CCDS42657.1
      UniProtKB/Swiss-Prot
      A6NI15
      Related
      ENSP00000281047.3, ENST00000281047.4
      Conserved Domains (1) summary
      pfam00010
      Location:125179
      HLH; Helix-loop-helix DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      17816460..17817798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      17848194..17849532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)