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    bib big brain [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34330, updated on 4-Apr-2024

    Summary

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    Official Symbol
    bibprovided by FlyBase
    Official Full Name
    big brainprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000180
    Locus tag
    Dmel_CG4722
    See related
    AllianceGenome:FB:FBgn0000180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bib; BIB; BIB_DROME; CG4722; DmBIB; Dmel\CG4722; EP(2)2278; l(2)neo66; l(2)neo91; m-bib
    Summary
    Enables cation channel activity. Involved in cell-cell adhesion and mesoderm development. Is integral component of membrane. Is expressed in several structures, including epithelium; extended germ band embryo; gut section; presumptive embryonic/larval central nervous system; and thoracic segment. Human ortholog(s) of this gene implicated in nephrogenic diabetes insipidus. Orthologous to several human genes including AQP1 (aquaporin 1 (Colton blood group)) and AQP2 (aquaporin 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    30F5-30F5; 2-38 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9984645..9995538)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9984645..9995538)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene DNA replication-related element factor Neighboring gene Ribosomal protein L13 Neighboring gene long non-coding RNA:CR13130 Neighboring gene uncharacterized protein Neighboring gene Sister of Yb Neighboring gene antisense RNA:CR44873 Neighboring gene Nucleosome-destabilizing factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fundamental structural and functional properties of Aquaporin ion channels found across the kingdoms of life. Kourghi M, et al. Clin Exp Pharmacol Physiol, 2018 Apr. PMID 29193257
    2. Divalent Cations Regulate the Ion Conductance Properties of Diverse Classes of Aquaporins. Kourghi M, et al. Int J Mol Sci, 2017 Nov 3. PMID 29099773, Free PMC Article
    3. Drosophila big brain does not act as a water channel, but mediates cell adhesion. Tatsumi K, et al. FEBS Lett, 2009 Jun 18. PMID 19467350
    4. Dominant-negative suppression of big brain ion channel activity by mutation of a conserved glutamate in the first transmembrane domain. Yool AJ. Gene Expr, 2007. PMID 17708419, Free PMC Article
    5. Block by extracellular divalent cations of Drosophila big brain channels expressed in Xenopus oocytes. Yanochko GM, et al. Biophys J, 2004 Mar. PMID 14990474, Free PMC Article

    See all (183) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bib-transfected L cells formed aggregated clusters, while control-L cells remained as a single cell suspension. Ion permeation was not confirmed in L cells stably expressing Bib.
      Title: Drosophila big brain does not act as a water channel, but mediates cell adhesion.
    2. Big brain, a Drosophila homologue of mammalian aquaporin, is regulated by the DRE/DREF system
      Title: Big brain, a Drosophila homologue of mammalian aquaporin, is regulated by the DRE/DREF system.
    3. The dominant-negative construct of BIB could be a tool for testing a role for BIB ion channels during nervous system development in Drosophila.
      Title: Dominant-negative suppression of big brain ion channel activity by mutation of a conserved glutamate in the first transmembrane domain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables water transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    big brain
    Names
    Big brain
    CG4722-PA
    CG4722-PB
    bib-PA
    bib-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9984645..9995538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057489.5 → NP_476837.1  big brain, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476837.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23645, Q9VL53
      Related
      FBpp0079519
      Conserved Domains (1) summary
      pfam00230
      Location:58 → 273
      MIP; Major intrinsic protein

    2. NM_001273384.2 → NP_001260313.1  big brain, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260313.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB86
      Conserved Domains (1) summary
      pfam00230
      Location:58 → 273
      MIP; Major intrinsic protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PB86 M9PB86
    P23645.2 P23645

    Gene LinkOut

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